{"id":"W3137683977","doi":"10.1038/s41586-021-03368-8","title":"Identification of bacteria-derived HLA-bound peptides in melanoma","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":437,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institute for Advanced Research","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Medical Research Council; National Institutes of Health; Wellcome Trust","keywords":"Immune system; Biology; Human leukocyte antigen; Bacteria; Melanoma; Antigen; Intracellular parasite; Intracellular; Immunology; Microbiology; Cancer research; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001945099,0.00009928782,0.0002050168,0.00009335711,0.00005605042,0.00001369733,0.0001478361,0.0009608655,0.0006332678],"category_scores_gemma":[0.0001792033,0.0000932593,0.00007252279,0.000196794,0.00009576598,0.00009194423,0.0000353562,0.0008234832,0.00009067046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000241054,"about_ca_system_score_gemma":0.00009061662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001715775,"about_ca_topic_score_gemma":0.0000271697,"domain_scores_codex":[0.9990971,0.0002432065,0.0002948089,0.0001775988,0.00002662381,0.0001606526],"domain_scores_gemma":[0.9993905,0.0001110512,0.0001136943,0.0002787158,0.0001014618,0.000004587685],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003084222,0.00009560255,0.001145095,0.00001711952,0.00007362643,0.000007125655,0.0004867079,5.806107e-7,0.9941172,0.0004605222,0.0003716459,0.002916362],"study_design_scores_gemma":[0.0007057969,0.00003443718,0.1408012,0.00003354829,0.000008619931,0.00004375678,0.0002838092,3.169701e-7,0.8390232,0.0001320493,0.01885158,0.00008175722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701001,0.0284135,0.000009998492,0.0003354416,0.0007296674,0.00007970635,0.00002162926,0.00001795763,0.0002919771],"genre_scores_gemma":[0.9941452,0.0004104415,0.00003441617,0.0001674681,0.00001266036,0.000007389624,0.000121759,0.00001027375,0.005090359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.155094,"threshold_uncertainty_score":0.7411075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006695528589401182,"score_gpt":0.2464726870536173,"score_spread":0.2397771584642161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}