{"id":"W3137687237","doi":"10.20944/preprints202103.0643.v1","title":"An ‘’Omic’’ Overview of Fragile X Syndrome","year":2021,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Fragile X syndrome; FMR1; Fragile x; Neuroscience; Gene silencing; Phenotype; Regulator; Biology; Bioinformatics; Psychology; Medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002269259,0.0003361429,0.0004119935,0.00006092183,0.00004511098,0.00001738807,0.0007053548,0.0004093215,0.0005366247],"category_scores_gemma":[0.0000620263,0.0003880533,0.0002495081,0.00008023829,0.00008775765,0.000003300335,0.00208638,0.0003093651,0.00006201713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001831104,"about_ca_system_score_gemma":0.0002724277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006822378,"about_ca_topic_score_gemma":0.00002910431,"domain_scores_codex":[0.9978312,0.0001296649,0.000464609,0.001063667,0.0002309948,0.0002798891],"domain_scores_gemma":[0.9979185,0.000005676139,0.0002432872,0.001552639,0.000142681,0.0001372057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00002585482,0.0003104121,0.1145218,0.0003474765,0.0001730704,0.00001863549,0.0001536337,0.0009371305,0.8830606,0.00001656796,0.0000684125,0.000366421],"study_design_scores_gemma":[0.0002351451,0.00006652602,0.5419358,0.0001087101,0.00003715903,0.00001855665,0.00007859783,0.00002753684,0.4537628,0.0001234281,0.003230845,0.0003749467],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995667,0.001979287,0.00006689978,0.00007662961,0.0004170023,0.0003240358,0.00006441824,0.00001897269,0.001385786],"genre_scores_gemma":[0.9945841,0.003492445,0.0003958456,0.0002656712,0.0000243351,0.00006255987,0.0007869608,0.00005875264,0.0003293156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4292978,"threshold_uncertainty_score":0.9998571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08949266458549196,"score_gpt":0.3392456447205619,"score_spread":0.2497529801350699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}