{"id":"W3137762429","doi":"10.1371/journal.pgen.1009123","title":"Independent domains for recruitment of PRC1 and PRC2 by human XIST","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"XIST; Biology; X-inactivation; Genetics; PRC2; Chromatin; Heterochromatin; X chromosome; Histone H3; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002572082,0.0002888927,0.0001721651,0.0001596799,0.0001484721,0.0003018078,0.0002729126,0.0001583669,0.001431448],"category_scores_gemma":[0.0002632855,0.0003019972,0.0003465973,0.000119503,0.0002505376,0.0002124157,0.0005202923,0.0004940453,0.0005800942],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002865244,"about_ca_system_score_gemma":0.0002956782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005407458,"about_ca_topic_score_gemma":0.001973238,"domain_scores_codex":[0.9996835,0.00003822649,0.00003481202,0.00007013422,0.0001313243,0.00004207152],"domain_scores_gemma":[0.9997465,0.00005164139,0.00006852335,0.00005572934,0.00002623535,0.00005133792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003550209,0.000004785991,0.0002851165,0.0000182755,0.000003556975,0.0000220387,0.000009318161,0.0000463639,0.9989795,0.00008663132,0.00001169128,0.0004971109],"study_design_scores_gemma":[0.000009369805,0.00005884989,0.009904287,0.000005261029,0.00001224372,0.000358201,0.00001651994,0.001009745,0.9864758,0.00003995929,0.002105454,0.000004309936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850943,0.001349356,0.0112174,0.00006461316,0.00001535895,0.00003213008,0.0003191458,0.0001110237,0.001796568],"genre_scores_gemma":[0.9888254,0.0003049074,0.006065052,0.00003628859,0.000005339149,0.00004181817,0.001005637,0.00003426328,0.0036813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001431448,"threshold_uncertainty_score":0.004788637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605508175720152,"score_gpt":0.2720150969182483,"score_spread":0.2459600151610468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}