{"id":"W3137762429","doi":"10.1371/journal.pgen.1009123","title":"Independent domains for recruitment of PRC1 and PRC2 by human XIST","year":2021,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"XIST; Biology; X-inactivation; Genetics; PRC2; Chromatin; Heterochromatin; X chromosome; Histone H3; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000626961,0.0001135838,0.0001378989,0.00001288248,0.00006015141,0.0000182641,0.0001010309,0.0001126439,0.000006186423],"category_scores_gemma":[0.00001856473,0.0001219652,0.00005300145,0.00002721687,0.00005054152,7.08553e-7,0.0001350767,0.00003714944,4.844777e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001224521,"about_ca_system_score_gemma":0.000054298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001024013,"about_ca_topic_score_gemma":0.00003529902,"domain_scores_codex":[0.9992501,0.00002087637,0.0002108628,0.0002636563,0.00009537435,0.0001591913],"domain_scores_gemma":[0.9994447,0.000007853264,0.0000894347,0.000285751,0.0001088282,0.00006347551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009911081,0.0001522391,0.001662174,0.00006719287,0.00008779594,9.130495e-7,0.00005166595,0.00002027467,0.9966391,0.0002780288,0.0006216007,0.0004090703],"study_design_scores_gemma":[0.0007076446,0.0003291397,0.0004387845,0.00001163754,0.00004160222,0.000007520319,0.00008984317,0.0004654314,0.9749722,0.0004727922,0.02230724,0.0001561046],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963301,0.002077476,0.0006441461,0.00006221871,0.00004728009,0.000348563,0.00017912,0.000003859633,0.0003071701],"genre_scores_gemma":[0.9935616,0.000725304,0.004503388,0.000092267,0.00006878313,0.0000634992,0.0004393664,0.00002823444,0.0005175803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02168564,"threshold_uncertainty_score":0.4973597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605508175720152,"score_gpt":0.2720150969182483,"score_spread":0.2459600151610468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}