{"id":"W3137780865","doi":"10.2139/ssrn.3751796","title":"High Precursor Frequency and Promiscuity in Αβ T Cell Receptor Pairing Underpin CD8+ T-Cell Responses to an Immunodominant SARS-CoV-2 Nucleocapsid Epitope","year":2020,"lang":"en","type":"article","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Immunodominance; CD8; Biology; Cytotoxic T cell; Epitope; T-cell receptor; T cell; Virology; Immunology; Population; Peripheral blood mononuclear cell; Immunophenotyping; Antigen; Immune system; Genetics; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001775295,0.0001750637,0.000164219,0.0001788521,0.0001588036,0.0004182814,0.0001247663,0.0002449807,0.003055987],"category_scores_gemma":[0.000404051,0.0001950046,0.00009495663,0.00009411986,0.0001395019,0.0003049434,0.0003424461,0.0005542173,0.0007568179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001205995,"about_ca_system_score_gemma":0.0001720406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000122401,"about_ca_topic_score_gemma":0.0002141122,"domain_scores_codex":[0.9998733,0.00002127615,0.00001214355,0.00003666532,0.00002054566,0.00003610014],"domain_scores_gemma":[0.9998152,0.0000548982,0.00003308521,0.00002938058,0.00002509215,0.00004225614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001773816,0.00002198712,0.0006069997,0.00001492821,0.000001320951,0.00004691856,0.00002793612,0.00007558033,0.9971661,0.0001453909,0.00002214436,0.001693271],"study_design_scores_gemma":[0.00006819121,0.0009919346,0.03436287,0.00001938156,0.00002643403,0.001244137,0.000283996,0.004903132,0.9541486,0.0008996155,0.003038913,0.00001283572],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971011,0.000146679,0.001203234,0.00002838357,0.00001259196,0.00001307526,0.00005852717,0.00003212981,0.001404215],"genre_scores_gemma":[0.9984016,0.00008985429,0.0007995713,0.00001968464,0.00001038671,0.00001096537,0.00008241875,0.000008982802,0.0005765643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003055987,"threshold_uncertainty_score":0.01022333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03241007301251837,"score_gpt":0.3130781712124261,"score_spread":0.2806680981999077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}