{"id":"W3137825255","doi":"10.1002/hep4.1692","title":"Experimental Models of Liquid Biopsy in Hepatocellular Carcinoma Reveal Clone‐Dependent Release of Circulating Tumor DNA","year":2021,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Deutsche Forschungsgemeinschaft; Universitätsklinikum Hamburg-Eppendorf; U.S. Department of Defense; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Science Foundation","keywords":"Hepatocellular carcinoma; Liquid biopsy; clone (Java method); DNA; Circulating tumor DNA; Pathology; Cancer research; Chemistry; Biology; Medicine; Cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001303858,0.0001135323,0.0002585147,0.00005982248,0.000057349,0.000004068935,0.0003944264,0.0001144252,0.00001156767],"category_scores_gemma":[0.0001072465,0.0001410813,0.00009643567,0.0001311104,0.0001947882,0.000004229038,0.0005565478,0.0001151507,0.000001219253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003762243,"about_ca_system_score_gemma":0.0003043249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004900591,"about_ca_topic_score_gemma":0.000166556,"domain_scores_codex":[0.9988751,0.0001683079,0.0004761915,0.0002363182,0.00007569451,0.0001683294],"domain_scores_gemma":[0.9981623,0.00006467487,0.0001936523,0.001373097,0.0001525281,0.00005374838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006250547,0.0003595698,0.04935733,0.00002488402,0.00002806093,0.00002739062,0.0002204548,0.0002011771,0.9459133,0.003712903,0.00004260061,0.00004979432],"study_design_scores_gemma":[0.0006877408,0.000183496,0.001542974,0.00002787359,0.00002399676,0.0001403806,0.0004521852,0.006868632,0.9894344,0.0002983728,0.0001796488,0.0001603645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888239,0.009365754,0.0003900449,0.0001716982,0.00005481148,0.0001401546,0.00007556551,0.000004219731,0.0009738553],"genre_scores_gemma":[0.9956836,0.0004505812,0.003398259,0.0001048617,0.00001664376,0.0000454287,0.0002621063,0.00001787745,0.00002065509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04781436,"threshold_uncertainty_score":0.575313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091998864892701,"score_gpt":0.2750119453889431,"score_spread":0.2440919567400161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}