{"id":"W3137825255","doi":"10.1002/hep4.1692","title":"Experimental Models of Liquid Biopsy in Hepatocellular Carcinoma Reveal Clone‐Dependent Release of Circulating Tumor DNA","year":2021,"lang":"en","type":"article","venue":"Hepatology Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Deutsche Forschungsgemeinschaft; Universitätsklinikum Hamburg-Eppendorf; U.S. Department of Defense; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Cancer Institute; National Science Foundation","keywords":"Hepatocellular carcinoma; Liquid biopsy; clone (Java method); DNA; Circulating tumor DNA; Pathology; Cancer research; Chemistry; Biology; Medicine; Cancer; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002931961,0.0003871859,0.0002525397,0.0003108641,0.0001564034,0.0002600354,0.000248478,0.0003786303,0.001182874],"category_scores_gemma":[0.0002234247,0.0001438959,0.0002979008,0.0001890015,0.0003432298,0.0003311015,0.0002604371,0.0006968862,0.0003776372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00048825,"about_ca_system_score_gemma":0.0002838988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147999,"about_ca_topic_score_gemma":0.001437607,"domain_scores_codex":[0.9997209,0.00006135598,0.00001891353,0.00006294333,0.00009533526,0.00004055947],"domain_scores_gemma":[0.9997236,0.00007443966,0.00008422948,0.00005253001,0.00002326115,0.00004189571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001844092,0.0001312697,0.0007084942,0.00005330329,0.000007646978,0.00008791956,0.0000375682,0.0002229648,0.9967308,0.0002160635,0.00005991073,0.001559766],"study_design_scores_gemma":[0.00002338592,0.001478773,0.004559176,0.000009138382,0.00002211743,0.0003518161,0.00004000979,0.003557567,0.9885215,0.0001157059,0.001311387,0.00000948655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613873,0.001610997,0.03408807,0.0001624147,0.00006017618,0.0001748156,0.0005926898,0.0003088709,0.001614673],"genre_scores_gemma":[0.9860091,0.0007925506,0.009357629,0.0000753406,0.00001091868,0.0001876635,0.0007695514,0.00003538225,0.002762037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182874,"threshold_uncertainty_score":0.003957152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03091998864892701,"score_gpt":0.2750119453889431,"score_spread":0.2440919567400161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}