{"id":"W3137837510","doi":"10.3389/fbioe.2021.642465","title":"Preconditioning Human Adipose-Derived Stromal Cells on Decellularized Adipose Tissue Scaffolds Within a Perfusion Bioreactor Modulates Cell Phenotype and Promotes a Pro-regenerative Host Response","year":2021,"lang":"en","type":"article","venue":"Frontiers in Bioengineering and Biotechnology","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Adipose tissue; Stromal vascular fraction; Stromal cell; Decellularization; Cell biology; Chemistry; Mesenchymal stem cell; Biology; Cancer research; Extracellular matrix; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002467601,0.0003851673,0.0006174535,0.0005959807,0.000144672,0.0000343065,0.00008042722,0.0005207088,0.00001266709],"category_scores_gemma":[0.0001332861,0.0003321059,0.00004190379,0.0004085597,0.0002723684,0.00005494156,0.00007720946,0.0004592618,0.000002007377],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001098548,"about_ca_system_score_gemma":0.00007049616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001943908,"about_ca_topic_score_gemma":0.00000691394,"domain_scores_codex":[0.9983629,0.00008770657,0.0003548333,0.0006409129,0.0001526879,0.0004009643],"domain_scores_gemma":[0.999319,0.00004798563,0.000085948,0.0003090514,0.00006963113,0.0001683522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002960998,0.000152032,0.0005385905,0.0001679052,0.00008012616,0.000223567,0.000814195,0.0003285617,0.9957691,0.0001548129,0.00008099869,0.001393982],"study_design_scores_gemma":[0.002391397,0.001800736,0.003957586,0.0005149705,0.00009193482,0.0001339888,0.0004381642,0.01211976,0.9777507,0.00001794175,0.0004393716,0.0003434359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786355,0.01264997,0.006275305,0.00108184,0.000545108,0.0005102806,0.00002361167,0.0002702468,0.000008075663],"genre_scores_gemma":[0.9609361,0.0002300477,0.03766003,0.00001992179,0.0001114828,0.00003750847,0.00006851093,0.00005782191,0.0008785461],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03138473,"threshold_uncertainty_score":0.9999131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008573561940452895,"score_gpt":0.2250910624500703,"score_spread":0.2165175005096174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}