{"id":"W3137853903","doi":"10.1158/1078-0432.ccr-21-0315","title":"Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Veterinary Oncology Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Center for Advancing Translational Sciences; Virginia-Maryland College of Veterinary Medicine; Ohio State University; Cancer Center, University of Colorado; National Cancer Institute; National Institutes of Health; University of California, Davis; Morris Animal Foundation","keywords":"Medicine; Carboplatin; Osteosarcoma; Sirolimus; Internal medicine; Clinical endpoint; Oncology; Adjuvant therapy; Adverse effect; Population; Clinical trial; Chemotherapy; Surgery; Pathology; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01662554,0.000279463,0.003261215,0.0004140985,0.0001241636,0.00003242266,0.0004786101,0.0003571175,0.0004530327],"category_scores_gemma":[0.01613382,0.0001870888,0.0009767084,0.0007386557,0.001672486,0.000102966,0.0004716826,0.001889927,0.000005512801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005659499,"about_ca_system_score_gemma":0.00333731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003699228,"about_ca_topic_score_gemma":0.0004672434,"domain_scores_codex":[0.9907935,0.003158309,0.002279277,0.001036556,0.001760657,0.0009716756],"domain_scores_gemma":[0.9858692,0.009910848,0.0003516408,0.0009569653,0.002585444,0.0003258741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8878648,0.001183021,0.0750571,0.001204078,0.0003760258,0.0005878508,0.0005717456,0.000001435396,0.01319273,0.00008541033,0.00006270501,0.01981308],"study_design_scores_gemma":[0.9481535,0.02304834,0.01184513,0.0005098529,0.00009906285,0.0000457018,0.000820904,0.0001154851,0.01318322,0.0007348069,0.001225312,0.0002186699],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798632,0.003321115,0.00004609839,0.004794259,0.000754891,0.01042149,0.0003189602,0.00002675008,0.0004532404],"genre_scores_gemma":[0.9902796,0.003437338,0.001676165,0.0001137714,0.0005624269,0.002868775,0.00003763575,0.00007116518,0.0009531621],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06321196,"threshold_uncertainty_score":0.9921537,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1637366620973989,"score_gpt":0.5384553562192401,"score_spread":0.3747186941218412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}