{"id":"W3137853903","doi":"10.1158/1078-0432.ccr-21-0315","title":"Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs","year":2021,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Veterinary Oncology Research","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Center for Advancing Translational Sciences; Virginia-Maryland College of Veterinary Medicine; Ohio State University; Cancer Center, University of Colorado; National Cancer Institute; National Institutes of Health; University of California, Davis; Morris Animal Foundation","keywords":"Medicine; Carboplatin; Osteosarcoma; Sirolimus; Internal medicine; Clinical endpoint; Oncology; Adjuvant therapy; Adverse effect; Population; Clinical trial; Chemotherapy; Surgery; Pathology; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002268877,0.001388388,0.00257725,0.0003432823,0.0003515978,0.001037518,0.0007355529,0.001829878,0.002981054],"category_scores_gemma":[0.001807158,0.0005584238,0.001593043,0.0003357505,0.001556303,0.0008993153,0.0003778525,0.001978661,0.0004297995],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008949059,"about_ca_system_score_gemma":0.0009757892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005743719,"about_ca_topic_score_gemma":0.001078703,"domain_scores_codex":[0.9989429,0.0005809296,0.00007468561,0.0001918251,0.00007818405,0.0001314679],"domain_scores_gemma":[0.9984452,0.0003058556,0.0005850641,0.000188137,0.00008528123,0.0003903886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.980924,0.009344291,0.001846953,0.0001483485,0.0005099206,0.00002207275,0.00002569618,0.0002321651,0.002326363,0.00004785476,0.0001930376,0.00437938],"study_design_scores_gemma":[0.6659304,0.3237522,0.006635042,0.00003586769,0.0007824663,0.00006352139,0.00005413835,0.0008478053,0.001152912,0.0001417184,0.0005828481,0.00002111966],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976729,0.000785491,0.0001370401,0.0001640265,0.0001081482,0.0006250601,0.0001990709,0.0000130945,0.0002952724],"genre_scores_gemma":[0.9962056,0.0006324255,0.0004390039,0.0002970826,0.0001915804,0.0009329669,0.0004214025,0.000006002,0.000873927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002981054,"threshold_uncertainty_score":0.01199913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1637366620973989,"score_gpt":0.5384553562192401,"score_spread":0.3747186941218412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}