{"id":"W3137856571","doi":"10.1093/eurheartj/ehab107","title":"Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality","year":2021,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Nursing Research; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Hjärt-Lungfonden; Sociale en Geesteswetenschappen, NWO; European Commission; European Regional Development Fund; Health Research Council of New Zealand; Deutsche Forschungsgemeinschaft; AstraZeneca; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Inflammasome; Systemic inflammation; Medicine; Inflammation; Immunology; Allele; Single-nucleotide polymorphism; Coronary artery disease; Internal medicine; Gene; Genotype; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004365091,0.0004533598,0.0004092252,0.0003907072,0.0002160131,0.0003017888,0.0002011654,0.0004368879,0.002296253],"category_scores_gemma":[0.000901647,0.0001434233,0.0005223819,0.0005619684,0.0003316563,0.0001231429,0.0003105865,0.0003655576,0.0002523669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001214219,"about_ca_system_score_gemma":0.0001699816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006294664,"about_ca_topic_score_gemma":0.0005169474,"domain_scores_codex":[0.9995602,0.0001497672,0.00004443675,0.0001658363,0.00004783143,0.00003198645],"domain_scores_gemma":[0.9992988,0.0001385205,0.0003841667,0.0000709917,0.00003506831,0.00007251758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001259226,0.00007156175,0.9690279,0.00009280866,0.0007151335,0.0007511156,0.0001292424,0.0001810817,0.02306803,0.0001019837,0.0001776664,0.004424286],"study_design_scores_gemma":[0.00002352735,0.000281453,0.9951307,0.00001571818,0.0003199385,0.002009132,0.00006796861,0.0003777822,0.001325731,0.0001800888,0.0002611618,0.000006780284],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984179,0.0005849669,0.0004734977,0.00004457962,0.000006866334,0.000006316618,0.0002670037,0.00001189566,0.0001870266],"genre_scores_gemma":[0.9991641,0.0001357307,0.0003456149,0.00001575852,0.000009376054,0.000007255265,0.0001853168,0.000004399685,0.00013237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002296253,"threshold_uncertainty_score":0.007681668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368827896032903,"score_gpt":0.2328265035133529,"score_spread":0.2191382245530238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}