{"id":"W3137856571","doi":"10.1093/eurheartj/ehab107","title":"Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality","year":2021,"lang":"en","type":"article","venue":"European Heart Journal","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Institute of Nursing Research; National Center for Advancing Translational Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; Hjärt-Lungfonden; Sociale en Geesteswetenschappen, NWO; European Commission; European Regional Development Fund; Health Research Council of New Zealand; Deutsche Forschungsgemeinschaft; AstraZeneca; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Inflammasome; Systemic inflammation; Medicine; Inflammation; Immunology; Allele; Single-nucleotide polymorphism; Coronary artery disease; Internal medicine; Gene; Genotype; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006869871,0.0001542759,0.000189875,0.00003959184,0.0001961355,0.0001408669,0.00008524897,0.00006381495,0.00001363652],"category_scores_gemma":[0.0001662744,0.00013718,0.0001440392,0.00008143806,0.00005035669,0.00002119105,0.00007975139,0.0001765107,0.00001097515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001614046,"about_ca_system_score_gemma":0.0001090271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001877636,"about_ca_topic_score_gemma":0.000004220521,"domain_scores_codex":[0.9985475,0.0004631779,0.0002739473,0.0002500142,0.000236373,0.0002289926],"domain_scores_gemma":[0.9992499,0.00001170889,0.0001062287,0.0002938099,0.0002474467,0.00009085073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005578158,0.00001758308,0.07289318,0.00003630176,0.0005434784,0.00009502785,0.0001294893,0.000455097,0.9211017,0.00001483609,0.0002646857,0.004392839],"study_design_scores_gemma":[0.002328557,0.000415567,0.5449042,0.0001844912,0.0001972944,0.002583279,0.0004509397,0.00008266327,0.4167616,0.00003864248,0.03150738,0.0005453345],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954637,0.001888632,0.001321714,0.0001282507,0.00009059388,0.0001027078,0.000001514105,0.00001214009,0.0009907972],"genre_scores_gemma":[0.9979965,0.0005751139,0.0005846223,0.00009650475,0.0004799679,0.000002986333,0.00004312432,0.00003382089,0.0001873776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5043401,"threshold_uncertainty_score":0.5594039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368827896032903,"score_gpt":0.2328265035133529,"score_spread":0.2191382245530238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}