{"id":"W3137922604","doi":"10.1038/s41467-021-21950-6","title":"Reply to ‘Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation?’","year":2021,"lang":"en","type":"letter","venue":"Nature Communications","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network","funders":"","keywords":"Atrial fibrillation; Induced pluripotent stem cell; Cardiology; Beat (acoustics); Medicine; Internal medicine; Stem cell; Pharmacology; Biology; Embryonic stem cell; Cell biology; Genetics; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006324925,0.001223817,0.001836002,0.0009541303,0.004407018,0.004262906,0.002249911,0.06775569,0.005407377],"category_scores_gemma":[0.03066865,0.001470664,0.001644096,0.0007545153,0.004053135,0.004738827,0.002528385,0.06331583,0.007274793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004325473,"about_ca_system_score_gemma":0.005535461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006024943,"about_ca_topic_score_gemma":0.01089249,"domain_scores_codex":[0.9947528,0.001210023,0.0006987084,0.0007657976,0.001753372,0.0008192649],"domain_scores_gemma":[0.9877358,0.007754634,0.0008963171,0.0003123995,0.001694582,0.001606218],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009236499,0.00003444056,0.0002655801,0.00004366643,0.00002319571,0.000523309,0.0001131624,0.00004500956,0.0001988045,0.001722086,0.9927934,0.004144953],"study_design_scores_gemma":[0.0002279014,0.0001527125,0.001907951,0.0002649596,0.00007345898,0.0007428625,0.0004356381,0.0005097995,0.0005149612,0.01042018,0.984615,0.0001346429],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0002380437,0.001074674,0.0001229029,0.9683183,0.0289692,0.00001201849,0.00008815459,0.0000284113,0.001148336],"genre_scores_gemma":[0.00123826,0.0004619627,0.0001318308,0.9766693,0.01824482,0.00003276233,0.00003365458,0.00001454938,0.003172822],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06775569,"threshold_uncertainty_score":0.03344983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03877736043333574,"score_gpt":0.3348262456297305,"score_spread":0.2960488851963948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}