{"id":"W3137933781","doi":"10.1177/0269881120986422","title":"Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action","year":2021,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Psilocybin; Hallucinogen; Lysergic acid diethylamide; Serotonergic; Antidepressant; Ayahuasca; 5-HT2A receptor; Pharmacology; Psychology; Medicine; Serotonin Antagonists; Psychiatry; Anxiety; Serotonin; 5-HT receptor; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001722316,0.0004991966,0.0009432233,0.0007372047,0.0001456059,0.0008745886,0.0006409572,0.001004596,0.003715021],"category_scores_gemma":[0.001411936,0.0001795119,0.0004842182,0.000609763,0.0006833301,0.0008920115,0.0004235731,0.001056507,0.0006517625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004484376,"about_ca_system_score_gemma":0.0005269138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005512749,"about_ca_topic_score_gemma":0.00130639,"domain_scores_codex":[0.9996533,0.0001248249,0.00004293833,0.00005455803,0.00009549534,0.00002892453],"domain_scores_gemma":[0.998772,0.0006273297,0.0003206049,0.00004175023,0.0001706161,0.00006768115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003620416,0.0005306394,0.001483531,0.01398784,0.0004156977,0.0004463119,0.00008864222,0.0003024808,0.00885541,0.004333972,0.004108796,0.9618263],"study_design_scores_gemma":[0.008465526,0.04805017,0.0803136,0.04823846,0.005556449,0.009437372,0.0009146038,0.002187354,0.03023659,0.02019392,0.7461232,0.0002827359],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005472828,0.9917794,0.0001518038,0.0009877802,0.00007990044,0.00001690222,0.00004222968,0.000007691453,0.001461472],"genre_scores_gemma":[0.0575151,0.9392667,0.0006765822,0.001311041,0.0005489975,0.00003560022,0.00009424482,0.000003730798,0.0005480426],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003715021,"threshold_uncertainty_score":0.01242793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004651775819469,"score_gpt":0.4282313773940052,"score_spread":0.3277661998120583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}