{"id":"W3137933781","doi":"10.1177/0269881120986422","title":"Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action","year":2021,"lang":"en","type":"article","venue":"Journal of Psychopharmacology","topic":"Psychedelics and Drug Studies","field":"Psychology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Psilocybin; Hallucinogen; Lysergic acid diethylamide; Serotonergic; Antidepressant; Ayahuasca; 5-HT2A receptor; Pharmacology; Psychology; Medicine; Serotonin Antagonists; Psychiatry; Anxiety; Serotonin; 5-HT receptor; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009581207,0.0002770225,0.0007053869,0.00025442,0.0001269943,0.00002934338,0.0003321772,0.0002429184,0.00302385],"category_scores_gemma":[0.00008273259,0.000246355,0.0002855904,0.0003324319,0.0002002335,0.0001850509,0.00008098676,0.0005147654,0.00006428888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004686313,"about_ca_system_score_gemma":0.0001569675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002629464,"about_ca_topic_score_gemma":0.0000103638,"domain_scores_codex":[0.9972221,0.0005378215,0.001061709,0.0004244597,0.0003561276,0.0003977585],"domain_scores_gemma":[0.9972596,0.0004544408,0.00105809,0.0003357739,0.0007089328,0.0001831289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002587609,0.0009470842,0.001541456,0.00008220739,0.00212095,0.0001968055,0.002183227,0.000008215028,0.9312532,0.00478284,0.02471419,0.02958221],"study_design_scores_gemma":[0.03323831,0.008922274,0.1093642,0.001115398,0.003512637,0.01053795,0.01884803,0.0001351709,0.5232357,0.06554129,0.2233681,0.002180884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9233791,0.05046583,0.002947407,0.00800206,0.01128463,0.0002322521,0.00001344602,0.00002317433,0.003652057],"genre_scores_gemma":[0.9733543,0.02184939,0.001359171,0.002346662,0.0005589347,0.00001453664,0.000001345102,0.0000360679,0.0004796095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4080175,"threshold_uncertainty_score":0.9999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004651775819469,"score_gpt":0.4282313773940052,"score_spread":0.3277661998120583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}