{"id":"W3138025188","doi":"10.1158/0008-5472.can-20-3348","title":"The Landscape of the Heritable Cancer Genome","year":2021,"lang":"en","type":"letter","venue":"Cancer Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia Graduate School; University of British Columbia; Cancer Research UK","keywords":"Cancer; Genome; Biology; Genetics; Evolutionary biology; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002523088,0.00021772,0.0005113303,0.001944082,0.0004828143,0.001607047,0.0004024294,0.0005590991,0.002352714],"category_scores_gemma":[0.0110567,0.0002479122,0.0005837303,0.001921651,0.001336534,0.0007577849,0.0009506303,0.000888454,0.0001844021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000549815,"about_ca_system_score_gemma":0.0002833218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003078943,"about_ca_topic_score_gemma":0.002511701,"domain_scores_codex":[0.9976141,0.001109303,0.0000634508,0.0007637647,0.0003339525,0.0001153887],"domain_scores_gemma":[0.9913482,0.006496855,0.0009167601,0.0006365791,0.0004330674,0.0001685197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003985714,0.00007746507,0.6927132,0.0003327741,0.002607684,0.001178176,0.0009101682,0.03531016,0.05360366,0.06398322,0.004682708,0.1442022],"study_design_scores_gemma":[0.0000332325,0.0001229121,0.8410675,0.00004017238,0.0004378828,0.000824421,0.00030378,0.0602615,0.002648854,0.08836577,0.005829541,0.00006443676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.9098967,0.004479742,0.07521284,0.003593613,0.00005062415,0.00002339209,0.001818849,0.0005322878,0.004391882],"genre_scores_gemma":[0.9934953,0.0002955739,0.005048574,0.0002963837,0.00005394209,0.0000146181,0.0004502354,0.00004907578,0.0002963484],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.003078943,"threshold_uncertainty_score":0.01334357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05187474536256996,"score_gpt":0.3690926799973182,"score_spread":0.3172179346347482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}