{"id":"W3138029987","doi":"10.1016/j.jbc.2021.100589","title":"Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA","year":2021,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Alberta; University of Calgary; University of Lethbridge","funders":"Cumming School of Medicine, University of Calgary; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Foundation for Innovation","keywords":"cccDNA; HBx; Hepatitis B virus; Biology; Virology; Hepatitis B virus PRE beta; Molecular biology; Virus; Hepatitis B virus DNA polymerase; HBsAg","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221759,0.00008958756,0.0003437352,0.00002489507,0.00002087838,0.000007406529,0.00007988349,0.0001432944,0.00004682682],"category_scores_gemma":[0.0004695915,0.00005505154,0.00008002577,0.0001503831,0.0001225914,0.00004375407,0.00002910326,0.0002021936,1.282756e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003151175,"about_ca_system_score_gemma":0.00005455887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001983639,"about_ca_topic_score_gemma":0.00001013395,"domain_scores_codex":[0.998928,0.00006964569,0.000581826,0.0001226412,0.000210867,0.00008703597],"domain_scores_gemma":[0.9989232,0.0000540414,0.0005500717,0.0001456339,0.0002938492,0.00003314461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00008009961,0.00009967219,0.2240078,0.0002427862,0.00003756476,0.00009282061,0.0003567305,2.046764e-7,0.7741721,0.000004201092,0.00001306724,0.0008929595],"study_design_scores_gemma":[0.000315296,0.00008346489,0.5438547,0.0001385929,0.0000329774,0.0003253117,0.00003106942,0.000016434,0.4549983,0.0001058511,0.00006656608,0.00003144543],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988406,0.0004512357,0.0000645734,0.0004312812,0.00002998692,0.0001253895,0.00003320163,0.000002622282,0.00002109699],"genre_scores_gemma":[0.9978017,0.001886846,0.0000647784,0.00008387444,0.00008957025,0.000002533532,0.00004615985,0.000004428576,0.00002013073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3198468,"threshold_uncertainty_score":0.2244937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0330821082961359,"score_gpt":0.2752222037175526,"score_spread":0.2421400954214167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}