{"id":"W3138038490","doi":"10.1038/s41598-021-84069-0","title":"Ligand modulation of the conformational dynamics of the A2A adenosine receptor revealed by single-molecule fluorescence","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Process Research Ortech (Canada); Dairy Farmers of Ontario; Becton Dickinson (Canada); Canada Research Chairs; University of Toronto","funders":"U.S. Department of Energy; Laboratory Directed Research and Development; Los Alamos National Laboratory; National Nuclear Security Administration; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Förster resonance energy transfer; G protein-coupled receptor; Ligand (biochemistry); Biophysics; Adenosine receptor; Transmembrane domain; Adenosine A2A receptor; Stereochemistry; Receptor; Fluorescence; Agonist; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004076113,0.00007528291,0.00009845116,0.00001495472,0.0001432159,0.00004556423,0.0001513783,0.00007350051,0.00005370256],"category_scores_gemma":[0.0002209473,0.00005015401,0.0001097868,0.0002352539,0.0001623351,0.000008720667,0.0001232506,0.00004986699,4.627003e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001681096,"about_ca_system_score_gemma":0.0001673495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005700014,"about_ca_topic_score_gemma":0.00001067241,"domain_scores_codex":[0.9988455,0.00005152967,0.00039123,0.000253518,0.0003491632,0.0001090278],"domain_scores_gemma":[0.9986241,0.000006250118,0.0004144585,0.0005610661,0.0003675625,0.00002653648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004358772,0.00003578225,0.001166225,0.0000168099,0.00001043744,5.089841e-7,0.00004520314,0.0001667674,0.9943379,0.0001063305,0.003830433,0.0002792058],"study_design_scores_gemma":[0.00007196995,0.00001616467,0.0005109623,0.00004566451,0.000008383428,0.00002561435,0.00006282804,0.0007917455,0.9956575,0.0004138371,0.002336168,0.00005916453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957089,0.0001894254,0.001515876,0.0002007898,0.001926692,0.0001456686,0.00002168439,0.000002656502,0.0002883531],"genre_scores_gemma":[0.9971212,0.000005481309,0.0004993778,0.00002370666,0.0000283367,0.000003117013,0.0002478238,0.000006599383,0.002064362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001898356,"threshold_uncertainty_score":0.2045221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006679640087913338,"score_gpt":0.2058106351546452,"score_spread":0.1991309950667319,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}