{"id":"W3138047597","doi":"10.1200/op.20.00949","title":"Challenges of Immunotherapy in Stage IV Non–Small-Cell Lung Cancer","year":2021,"lang":"en","type":"review","venue":"JCO Oncology Practice","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Hôpital du Sacré-Cœur de Montréal; University of Ottawa","funders":"","keywords":"Immunotherapy; Medicine; Lung cancer; Oncology; Adverse effect; Chemotherapy; Internal medicine; Immune system; Immune checkpoint; Targeted therapy; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001018572,0.0003873345,0.0009178052,0.001218514,0.0002319028,0.001115916,0.0005537585,0.001084492,0.002261064],"category_scores_gemma":[0.001291272,0.0001726375,0.0004662648,0.001022007,0.0004020799,0.001402942,0.0006311447,0.001845494,0.001262341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004868395,"about_ca_system_score_gemma":0.001208535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006680915,"about_ca_topic_score_gemma":0.001731795,"domain_scores_codex":[0.999752,0.00007403482,0.00003700906,0.00003212337,0.00008149727,0.00002328128],"domain_scores_gemma":[0.9993895,0.0003285492,0.00006892699,0.0000138095,0.0001583901,0.00004074429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004482091,0.00004061728,0.0002302155,0.01134932,0.00005321752,0.0001922455,0.00007404117,0.0002923081,0.0008711773,0.004574683,0.03978914,0.9424881],"study_design_scores_gemma":[0.00001115268,0.00007561829,0.0005449822,0.004975599,0.00006196697,0.0009853268,0.00007164205,0.0001024796,0.000243083,0.002716354,0.9901995,0.0000122039],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000100787,0.9976306,0.0001053001,0.001187371,0.0003012164,0.000002810474,0.000009425699,0.000004871165,0.0006575196],"genre_scores_gemma":[0.0008736679,0.9974415,0.000177161,0.0006608302,0.0004075195,0.000006142301,0.00001884848,0.000001766348,0.0004123746],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002261064,"threshold_uncertainty_score":0.007564068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09085460350274119,"score_gpt":0.44692957633113,"score_spread":0.3560749728283887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}