{"id":"W3138277529","doi":"10.1126/sciadv.abe0013","title":"Massive clonal expansion of polycytotoxic skin and blood CD8 <sup>+</sup> T cells in patients with toxic epidermal necrolysis","year":2021,"lang":"en","type":"article","venue":"Science Advances","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospices Civils de Lyon; Société Française de Dermatologie et de Pathologie Sexuellement Transmissible; Agence Nationale de la Recherche; Ministère de l'Économie, de la Science et de l'Innovation - Québec","keywords":"Toxic epidermal necrolysis; CD8; Dermatology; Medicine; Cytotoxic T cell; Immunology; Pathology; Chemistry; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002396606,0.0002128054,0.0002218735,0.0006145088,0.0002479864,0.000313603,0.0001051947,0.0002601314,0.001301904],"category_scores_gemma":[0.0008282322,0.0001413856,0.00009569831,0.0003034261,0.0002294892,0.0002134054,0.0001561251,0.0003329634,0.0002179873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001294949,"about_ca_system_score_gemma":0.00006899823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001468702,"about_ca_topic_score_gemma":0.0001967405,"domain_scores_codex":[0.9998285,0.00004172804,0.00002546261,0.00004511154,0.00003616186,0.00002299616],"domain_scores_gemma":[0.9996364,0.0001199682,0.00009992893,0.0000312199,0.00003896143,0.00007340802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001463004,0.0002082812,0.792552,0.0001214293,0.00005965688,0.0335698,0.0006938052,0.0004323177,0.1213134,0.0001896054,0.0006643506,0.04873243],"study_design_scores_gemma":[0.00005877567,0.001289922,0.8836884,0.00002392081,0.0001027901,0.0900377,0.0003151451,0.001411891,0.02130177,0.0001965854,0.001558646,0.00001439646],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986838,0.0002169831,0.0002554193,0.00003791534,0.000004473719,0.000008656855,0.00003254453,0.00001766514,0.0007425802],"genre_scores_gemma":[0.9996291,0.00006132981,0.000105449,0.00003321447,0.000009595051,0.00000247079,0.00002947948,0.000002685544,0.0001266098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001301904,"threshold_uncertainty_score":0.004355311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006825543887834404,"score_gpt":0.2476055469286444,"score_spread":0.24078000304081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}