{"id":"W3138286502","doi":"10.1371/journal.pone.0246157","title":"The nature of genetic and environmental susceptibility to multiple sclerosis","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Genetic predisposition; Genetics; Human leukocyte antigen; Locus (genetics); Biology; Haplotype; Population; Genetic epidemiology; Major histocompatibility complex; Multiple sclerosis; Epidemiology; Demography; Evolutionary biology; Allele; Medicine; Environmental health; Immunology; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001537877,0.00008804553,0.0002297592,0.00002375124,0.0001276637,0.00001275935,0.0000685605,0.00006153159,0.00008229529],"category_scores_gemma":[0.001360107,0.00006240699,0.00004305565,0.0001039899,0.0001920716,0.00001814408,0.0002523025,0.0002238903,0.00001263147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005060512,"about_ca_system_score_gemma":0.0000267746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001783178,"about_ca_topic_score_gemma":0.0001438092,"domain_scores_codex":[0.9988121,0.00006145812,0.0001745592,0.0002500075,0.0004918854,0.0002099761],"domain_scores_gemma":[0.999041,0.000319863,0.00002814014,0.000401156,0.00007045792,0.0001393589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00007026036,0.0006081354,0.3660027,0.00008321581,0.0001633853,0.000002301512,0.0001760535,4.330979e-7,0.6295256,0.00000157175,0.0001397105,0.003226618],"study_design_scores_gemma":[0.0005482568,0.000119542,0.7622026,0.0001216275,0.00005006025,8.332462e-7,0.0003785705,0.0001573513,0.2362449,0.000005282738,0.0001254543,0.00004562565],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944336,0.002935292,0.000004121096,0.001987812,0.00001327556,0.0004347364,0.00005354658,0.00001177574,0.0001257961],"genre_scores_gemma":[0.9928009,0.003233333,0.003355236,0.0001609347,0.00005662601,0.00003608116,0.000009483608,0.00001172337,0.0003356663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3961998,"threshold_uncertainty_score":0.2544883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07145760812810537,"score_gpt":0.2673060019201626,"score_spread":0.1958483937920572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}