{"id":"W3138322003","doi":"10.1093/brain/awab083","title":"The hedgehog pathway suppresses neuropathogenesis in CD4 T cell-driven inflammation","year":2021,"lang":"en","type":"article","venue":"Brain","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; China Scholarship Council; Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society of Canada; Public Health Agency of Canada; National Institutes of Health; National Institute of Neurological Disorders and Stroke; Cancer Research Institute","keywords":"Neuroinflammation; Experimental autoimmune encephalomyelitis; Hedgehog; Hedgehog signaling pathway; Biology; Immunology; Inflammation; Neuroscience; Cell biology; Signal transduction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002461728,0.0001346083,0.0001150559,0.00002547621,0.0001527358,0.00004644375,0.0001798364,0.0000868693,0.000009107992],"category_scores_gemma":[0.0006921758,0.0001116157,0.00006967122,0.000150145,0.00006408936,0.000003261719,0.0001814602,0.00007700826,0.00002178404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001121034,"about_ca_system_score_gemma":0.0001230713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006018927,"about_ca_topic_score_gemma":0.000235312,"domain_scores_codex":[0.9988366,0.00025277,0.0002239266,0.0003145883,0.0001216803,0.0002504115],"domain_scores_gemma":[0.9993111,0.0001122788,0.00005986266,0.0003734438,0.0001014879,0.00004176944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001620413,0.00002344598,0.002909308,0.00001865025,0.00001084915,0.00004578987,0.0001471119,0.0002057716,0.9891576,0.00006082575,0.001649965,0.005754475],"study_design_scores_gemma":[0.0002911796,0.0000434319,0.007065161,0.0000117964,0.000004098335,0.000008948678,0.0002075284,0.00008685014,0.8607106,0.00003524891,0.1314006,0.0001344751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945996,0.002115008,0.0002064269,0.001446645,0.0001817498,0.0001258573,0.00001912394,0.00001603013,0.001289519],"genre_scores_gemma":[0.997335,0.0003176359,0.000200458,0.0002920271,0.0002659257,0.00004219725,0.00007757464,0.0000248711,0.001444383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1297507,"threshold_uncertainty_score":0.4551557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008844483531826909,"score_gpt":0.2247030853209719,"score_spread":0.215858601789145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}