{"id":"W3138330141","doi":"10.1101/2021.03.12.435012","title":"Cdk8 directly regulates glycolysis via phosphorylation of Gcr2","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of Toronto; Queen's University; University of British Columbia; Canadian Institute for Advanced Research","funders":"Natural Sciences and Engineering Research Council of Canada; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Transcription (linguistics); Biology; Cyclin-dependent kinase 8; Gene; Mutant; Transcription factor; Phosphorylation; Promoter; Gene expression; Transcriptional regulation; Regulation of gene expression; Molecular biology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007340925,0.0003496075,0.0001728459,0.0001436597,0.0001346427,0.0003105004,0.0002051142,0.0001671225,0.002327884],"category_scores_gemma":[0.0001026208,0.0001248539,0.0001362976,0.0001046788,0.000236901,0.0001808816,0.0001880854,0.0002857971,0.0007127312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004170342,"about_ca_system_score_gemma":0.0001576787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007020918,"about_ca_topic_score_gemma":0.0008999749,"domain_scores_codex":[0.9999287,0.000008303145,0.00000364167,0.00002723421,0.00001477098,0.00001729033],"domain_scores_gemma":[0.9999518,0.000009470489,0.00001369725,0.000009176662,0.000004464132,0.00001134713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000943878,0.000006129114,0.0002082269,0.00002531397,0.00000190442,0.00004512863,0.000004834971,0.00009685586,0.9987173,0.0001613014,0.00004702616,0.0005915589],"study_design_scores_gemma":[0.000009206004,0.0000170865,0.002470454,0.000002242121,0.000002616694,0.0001095898,0.000007574747,0.0008364954,0.9950104,0.00007890705,0.001452865,0.000002539527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884409,0.002317804,0.004594086,0.0001870618,0.0000444909,0.00001533926,0.001170875,0.0001856606,0.003043726],"genre_scores_gemma":[0.9937872,0.000513615,0.001856009,0.00003599992,0.000008962688,0.00001043501,0.0007287521,0.00005170771,0.003007318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002327884,"threshold_uncertainty_score":0.007787585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005199121642858769,"score_gpt":0.1921907493458685,"score_spread":0.1869916277030097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}