{"id":"W3138375299","doi":"10.1038/s41467-021-22131-1","title":"Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute on Aging; National Institutes of Health; Johns Hopkins University; Tufts Medical Center","keywords":"Angiogenin; Angiogenesis; Senescence; Cell biology; Osteoclast; Biology; Transcription factor; Cancer research; Internal medicine; Endocrinology; Medicine; Receptor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001971651,0.0002494232,0.0001688067,0.0002575336,0.0002169319,0.0003425146,0.0001333866,0.000202826,0.001011235],"category_scores_gemma":[0.0001041238,0.00009762999,0.0001700327,0.00009566509,0.0002546121,0.0001857776,0.0002110581,0.0003966207,0.0001794486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002544602,"about_ca_system_score_gemma":0.0003282358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00051117,"about_ca_topic_score_gemma":0.001153451,"domain_scores_codex":[0.9998686,0.00002997052,0.000008391163,0.00002714027,0.0000387195,0.0000271834],"domain_scores_gemma":[0.9998839,0.00000853212,0.00004444546,0.00000799834,0.00001222501,0.00004286717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000170148,0.00002128354,0.0008134164,0.0000585855,0.00000861641,0.0001504109,0.00001904723,0.00005421235,0.9943896,0.0003692555,0.0001043155,0.003841041],"study_design_scores_gemma":[0.00008913012,0.0009722733,0.05428306,0.00002531654,0.00005059217,0.001880535,0.0001101205,0.001049884,0.9236787,0.0005673462,0.01727982,0.00001331701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735511,0.01389501,0.006784817,0.0004333907,0.00009050051,0.00003854559,0.0004668694,0.0002521627,0.004487513],"genre_scores_gemma":[0.9905036,0.002918518,0.002752238,0.00009501036,0.0000281856,0.00002884878,0.0001943381,0.00001157125,0.00346752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011235,"threshold_uncertainty_score":0.003382862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0172152719105308,"score_gpt":0.3044883025460016,"score_spread":0.2872730306354708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}