{"id":"W3138378728","doi":"10.1161/circulationaha.120.052604","title":"Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile","year":2021,"lang":"en","type":"letter","venue":"Circulation","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":67,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre for Global Health Research","funders":"Cancer Research UK; University of Pennsylvania Health System; U.S. Department of Veterans Affairs; Regeneron Pharmaceuticals; British Heart Foundation; University of Pennsylvania","keywords":"Medicine; Signal transduction; Interleukin; Immunology; Bioinformatics; Genetics; Cytokine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001711536,0.00040915,0.0008698663,0.0004052438,0.0001433992,0.000145054,0.0001019497,0.0007536085,0.001384097],"category_scores_gemma":[0.0001674795,0.0003660552,0.0003630971,0.0007965845,0.00006717809,0.0001017287,0.00003572968,0.001424061,0.00008226879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003579886,"about_ca_system_score_gemma":0.0004858158,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006943435,"about_ca_topic_score_gemma":0.000003812997,"domain_scores_codex":[0.9974894,0.0001361481,0.0005387602,0.0006910328,0.0006953314,0.0004493356],"domain_scores_gemma":[0.9979923,0.0001046687,0.0003334717,0.0005664263,0.0009011421,0.000102011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001427112,0.0003141521,0.006322595,0.0006728342,0.004632878,0.002271495,0.0008429554,0.00129235,0.3739612,0.00003677133,0.6057339,0.0037762],"study_design_scores_gemma":[0.007495699,0.0008799344,0.04599784,0.01127624,0.008610758,0.002361113,0.0002885211,0.0241797,0.1306756,0.0002468809,0.7646948,0.003292917],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7689619,0.001648823,0.006003957,0.2073153,0.001341285,0.002736598,0.0004224845,0.0007802907,0.01078943],"genre_scores_gemma":[0.8722122,0.00001246714,0.0005215604,0.1153065,0.002325151,0.00009568088,0.00753956,0.0001608435,0.001826],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2432856,"threshold_uncertainty_score":0.9998791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0288917035861585,"score_gpt":0.2540820392392877,"score_spread":0.2251903356531292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}