{"id":"W3138450947","doi":"10.2147/ptt.s303634","title":"Phosphodiesterase-4 Inhibition in Psoriasis","year":2021,"lang":"en","type":"review","venue":"Psoriasis Targets and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University; University of Toronto","funders":"","keywords":"Apremilast; Psoriasis; Roflumilast; Medicine; Phosphodiesterase; Pharmacology; Adenosine monophosphate; Phosphodiesterase inhibitor; Adverse effect; Adenosine; Atopic dermatitis; Cyclic adenosine monophosphate; Dermatology; Internal medicine; Enzyme; Chemistry; Psoriatic arthritis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003849829,0.0006539648,0.001193564,0.001900542,0.0001977065,0.0007072291,0.0005551933,0.0006971812,0.005594589],"category_scores_gemma":[0.0005545639,0.0002149262,0.0007975944,0.001559398,0.0002137487,0.0006468558,0.0005498328,0.001438594,0.001815799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004242001,"about_ca_system_score_gemma":0.0007713895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008280918,"about_ca_topic_score_gemma":0.001787354,"domain_scores_codex":[0.999813,0.00003562067,0.00002928051,0.00003349177,0.00006986904,0.00001868774],"domain_scores_gemma":[0.9998316,0.0000799464,0.00003094047,0.000005003616,0.00003798288,0.00001448828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001241931,0.00007396185,0.0001078636,0.03957559,0.0001864925,0.0001428112,0.00004580594,0.0002836735,0.001956591,0.001590611,0.02662179,0.9292905],"study_design_scores_gemma":[0.0000719973,0.0001987359,0.001129473,0.01082376,0.000491777,0.001570935,0.0000529799,0.0000997515,0.0007030578,0.001843907,0.982991,0.00002259281],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009465241,0.9991313,0.00004457095,0.00008923891,0.0001026174,0.000003975093,0.00001787261,0.000005594975,0.0005103457],"genre_scores_gemma":[0.0006950935,0.9986745,0.00008103539,0.0001141122,0.0000692983,0.000004750176,0.00003299361,0.000001147435,0.0003270782],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005594589,"threshold_uncertainty_score":0.01871574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911721463802153,"score_gpt":0.2921043110875625,"score_spread":0.252987096449541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}