{"id":"W3138450947","doi":"10.2147/ptt.s303634","title":"Phosphodiesterase-4 Inhibition in Psoriasis","year":2021,"lang":"en","type":"review","venue":"Psoriasis Targets and Therapy","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; SKiN Health; Queen's University; University of Toronto","funders":"","keywords":"Apremilast; Psoriasis; Roflumilast; Medicine; Phosphodiesterase; Pharmacology; Adenosine monophosphate; Phosphodiesterase inhibitor; Adverse effect; Adenosine; Atopic dermatitis; Cyclic adenosine monophosphate; Dermatology; Internal medicine; Enzyme; Chemistry; Psoriatic arthritis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004380324,0.0008937303,0.002688526,0.0004180684,0.0002296912,0.00007704982,0.0001642923,0.001056332,0.001018214],"category_scores_gemma":[0.00004613074,0.0006993797,0.0006662707,0.0004802562,0.0001278738,0.0001437241,0.0001015306,0.000476264,0.0002479406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001113732,"about_ca_system_score_gemma":0.0001798875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001249271,"about_ca_topic_score_gemma":0.00004244468,"domain_scores_codex":[0.9965354,0.0007987046,0.0009118018,0.00100699,0.00007753268,0.0006696323],"domain_scores_gemma":[0.9985594,0.0003874385,0.000382401,0.0005422152,0.00006790557,0.00006064196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006583654,0.0003337706,0.0000426533,0.0006175156,0.0009648868,0.00009888205,0.0003173791,8.082051e-8,0.0000249939,0.0002870892,0.001106616,0.9961403],"study_design_scores_gemma":[0.002892745,0.0001396,0.0000527685,0.002761732,0.0005083878,0.0001449172,0.00006816753,8.892297e-8,0.000526188,0.0001216537,0.9920821,0.0007016826],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001090531,0.9946741,0.000004976469,0.00004037579,0.002508316,0.0008268528,0.0002256497,0.00008707757,0.0005421075],"genre_scores_gemma":[0.0002346536,0.996035,0.00008696439,0.00009857407,0.0002560614,0.0004716556,0.001654418,0.00009862721,0.001064005],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9954386,"threshold_uncertainty_score":0.999895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03911721463802153,"score_gpt":0.2921043110875625,"score_spread":0.252987096449541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}