{"id":"W3138492443","doi":"10.3390/epigenomes5020007","title":"Enhancement of the Antileukemic Action of the Inhibitors of DNA and Histone Methylation: 5-Aza-2′-Deoxycytidine and 3-Deazaneplanocin-A by Vitamin C","year":2021,"lang":"en","type":"article","venue":"Epigenomes","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"EZH2; Epigenetics; Biology; DNA methylation; Histone H3; Histone; Cancer epigenetics; DNA demethylation; Histone methylation; Cancer research; Molecular biology; Histone methyltransferase; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003205337,0.0001119988,0.0003318996,0.00006116319,0.00006742813,0.000003815582,0.00009399584,0.00007619915,0.00008691866],"category_scores_gemma":[0.0001649771,0.00007044782,0.00007141256,0.0003267845,0.0003179528,0.00004677455,0.0001589434,0.0001746028,7.678993e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863322,"about_ca_system_score_gemma":0.0003121852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001396793,"about_ca_topic_score_gemma":0.00002316537,"domain_scores_codex":[0.9987954,0.0001182942,0.0003640657,0.0002000127,0.0003758654,0.0001463854],"domain_scores_gemma":[0.9990203,0.0001564232,0.0002376196,0.0003753146,0.0001611011,0.00004926921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006794333,0.00005799072,0.01044424,0.0002750271,0.00008562124,0.000001490597,0.0008650993,0.000001173561,0.9812832,0.00004642057,0.002043864,0.004827864],"study_design_scores_gemma":[0.0009183636,0.0001122986,0.04157252,0.0001184673,0.00007954286,0.00001772874,0.0004901241,0.00002905513,0.952738,0.00004839872,0.003819657,0.00005577292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913225,0.006067885,0.00004406657,0.001580734,0.0001645304,0.0003298667,0.00003086719,0.000005006883,0.0004545332],"genre_scores_gemma":[0.9957277,0.001412305,0.0001630513,0.00005435284,0.00006460778,0.00000686559,0.00001344512,0.00001349164,0.002544217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03112828,"threshold_uncertainty_score":0.2872779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599385217317148,"score_gpt":0.2908102401552441,"score_spread":0.2748163879820726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}