{"id":"W3138492443","doi":"10.3390/epigenomes5020007","title":"Enhancement of the Antileukemic Action of the Inhibitors of DNA and Histone Methylation: 5-Aza-2′-Deoxycytidine and 3-Deazaneplanocin-A by Vitamin C","year":2021,"lang":"en","type":"article","venue":"Epigenomes","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"EZH2; Epigenetics; Biology; DNA methylation; Histone H3; Histone; Cancer epigenetics; DNA demethylation; Histone methylation; Cancer research; Molecular biology; Histone methyltransferase; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001224364,0.0002380671,0.0002502023,0.0001962479,0.00008227742,0.0001638881,0.0001731965,0.0002161936,0.001042212],"category_scores_gemma":[0.0001461618,0.00006621006,0.0001630612,0.0001146781,0.0001014914,0.0001157497,0.0001327957,0.0002991388,0.0001218239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001928307,"about_ca_system_score_gemma":0.00021544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006754153,"about_ca_topic_score_gemma":0.0009024045,"domain_scores_codex":[0.9999052,0.00002321387,0.000009151092,0.00002015156,0.00002146551,0.00002078954],"domain_scores_gemma":[0.9999304,0.00001756963,0.00001608305,0.000006753099,0.00001272007,0.00001642294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003982893,0.0000432901,0.0002007576,0.0000929724,0.00001100649,0.00003454981,0.000008775841,0.0001216439,0.9917951,0.00008777117,0.00004391236,0.007161865],"study_design_scores_gemma":[0.00004985585,0.0008088236,0.002334199,0.000005978278,0.00001979367,0.0001958865,0.000007588307,0.000443161,0.9916071,0.00002224908,0.004501812,0.000003685152],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756798,0.01617235,0.003957263,0.0001155157,0.00005990477,0.00007610762,0.0003156469,0.0001049668,0.003518441],"genre_scores_gemma":[0.9931497,0.002729747,0.002237177,0.00003702164,0.00001009769,0.00003590417,0.0002545279,0.000006175183,0.001539712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001042212,"threshold_uncertainty_score":0.003486574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01599385217317148,"score_gpt":0.2908102401552441,"score_spread":0.2748163879820726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}