{"id":"W3138511534","doi":"10.1038/s41388-021-01755-z","title":"CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation","year":2021,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"National Health and Medical Research Council","keywords":"Biology; DNA methylation; Cancer research; Gene silencing; Kinase; Methyltransferase; Tumor suppressor gene; HEK 293 cells; Cell growth; Methylation; Gene expression; Cell biology; Molecular biology; Cell culture; Carcinogenesis; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001167742,0.0002628314,0.000262869,0.00003105387,0.0001222191,0.00006793056,0.000212778,0.0002749772,0.0004626432],"category_scores_gemma":[0.0001091916,0.0002797274,0.0001714291,0.0001226396,0.00009059319,0.000004894304,0.0002226087,0.0001164451,0.0000278578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000653114,"about_ca_system_score_gemma":0.000436264,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001479033,"about_ca_topic_score_gemma":0.0001557783,"domain_scores_codex":[0.9982502,0.0000865869,0.0003292749,0.0006786601,0.0002199268,0.0004353711],"domain_scores_gemma":[0.9990284,0.00002100442,0.0001225697,0.000351474,0.0002807176,0.0001958376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001533801,0.0001763682,0.0003466546,0.00001766031,0.0001120425,0.00007765451,0.00005923152,0.0002403337,0.9869445,0.000009082654,0.007320876,0.004542238],"study_design_scores_gemma":[0.000935945,0.0003246924,0.0008602141,0.00001136794,0.00009865252,0.00005906736,0.00002422435,0.000328319,0.9819131,0.0001173669,0.01496879,0.0003582877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9857163,0.008539725,0.002744756,0.000875982,0.0005244666,0.000280416,0.0009596523,0.00001836572,0.000340265],"genre_scores_gemma":[0.9915539,0.002608012,0.002326211,0.001002126,0.0006337216,0.0001217326,0.0008125504,0.00005815835,0.0008835862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007647919,"threshold_uncertainty_score":0.9999655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006553891759483123,"score_gpt":0.2510492960488694,"score_spread":0.2444954042893863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}