{"id":"W3138519498","doi":"10.1038/s41467-021-21883-0","title":"The transcriptional landscape of Shh medulloblastoma","year":2021,"lang":"en","type":"article","venue":"Nature Communications","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Toronto Western Hospital; University Health Network; McMaster University; Canada's Michael Smith Genome Sciences Centre; SickKids Foundation; BC Cancer Agency; McGill Genome Centre; Hamilton General Hospital; Simon Fraser University; McGill University Health Centre; McGill University; Princess Margaret Cancer Centre; University of Calgary; Ontario Institute for Cancer Research; Alberta Children's Hospital; University of Toronto; Hospital for Sick Children","funders":"National Center for Research Resources; National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute; National Institute of Mental Health; Canadian Cancer Society Research Institute; National Institutes of Health; National Heart, Lung, and Blood Institute; Broad Institute; Genome British Columbia; Hospital for Sick Children; Cancer Research UK; National Institute on Drug Abuse; Entertainment Industry Foundation; Stand Up To Cancer; Institute of Genetics; Brain Tumour Charity; Terry Fox Research Institute; Canadian Institutes of Health Research; Genome Canada; Compute Canada; Government of Canada; Ontario Institute for Cancer Research; Common Fund; Cancer Research Society; NIH Office of the Director; Van Andel Research Institute; University of Toronto; Brain Tumour Research; National Institute of Neurological Disorders and Stroke; Leidos; Government of Ontario; American Association for Cancer Research","keywords":"Medulloblastoma; Biology; GLI2; Sonic hedgehog; PTCH1; Hedgehog; Transcriptome; Gene; Genetics; GNAS complex locus; Hedgehog signaling pathway; Loss function; Computational biology; Cancer research; Phenotype; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008899865,0.00009116906,0.0001525769,0.000385999,0.0001795538,0.0003309989,0.00007225035,0.0001020587,0.0006973572],"category_scores_gemma":[0.000166453,0.00009660297,0.0001077086,0.0003154372,0.0002150072,0.0001170758,0.0001738444,0.000131876,0.0002157806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858505,"about_ca_system_score_gemma":0.0002379947,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001763984,"about_ca_topic_score_gemma":0.003844983,"domain_scores_codex":[0.9998792,0.00001099435,0.000004590193,0.00003972263,0.00003590589,0.00002951142],"domain_scores_gemma":[0.9999263,0.00001432991,0.00002337424,0.000006162707,0.00001350896,0.00001639245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001870524,0.000007510257,0.02534665,0.00003170751,0.00001589533,0.0001133435,0.0001841706,0.0002380207,0.969238,0.0003698681,0.0001333115,0.004134334],"study_design_scores_gemma":[0.000008764239,0.0001712104,0.8748855,0.00001526829,0.00005906912,0.0007145153,0.0007161822,0.002066569,0.1142231,0.001028134,0.006097148,0.00001453025],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969953,0.0006833221,0.0004437672,0.00007101419,0.0000036639,0.000002194154,0.0007046216,0.00002285083,0.0010732],"genre_scores_gemma":[0.9971657,0.0004496805,0.0003022183,0.00004552574,0.000006304449,0.000005078577,0.001078394,0.00001159451,0.0009354688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001763984,"threshold_uncertainty_score":0.003507435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547170461301908,"score_gpt":0.28506390514224,"score_spread":0.2695922005292209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}