{"id":"W3138524708","doi":"10.3390/genes12030419","title":"Set-Based Rare Variant Expression Quantitative Trait Loci in Blood and Brain from Alzheimer Disease Study Participants","year":2021,"lang":"en","type":"article","venue":"Genes","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research","keywords":"Expression quantitative trait loci; Biology; Quantitative trait locus; TREM2; Single-nucleotide polymorphism; Gene; Genome-wide association study; Genetics; Inflammation; Immunology; Microglia; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002271096,0.0001261744,0.0001899275,0.00002351474,0.0000654207,0.00001518,0.00007181076,0.000091628,0.00004712748],"category_scores_gemma":[0.0003415667,0.0001172776,0.0000440311,0.00006915299,0.00003735377,0.000002528519,0.00008366251,0.00005027558,0.00000290355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003792547,"about_ca_system_score_gemma":0.0001142829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001327681,"about_ca_topic_score_gemma":0.0005132991,"domain_scores_codex":[0.9986206,0.0004217021,0.00022732,0.0004200575,0.00007434906,0.0002359439],"domain_scores_gemma":[0.999427,0.00009260714,0.00006922423,0.0002437907,0.00005349985,0.0001138766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001229242,0.0004592995,0.7626211,0.000006543286,0.0001862588,0.0001248983,0.0007053029,0.000931327,0.2329434,0.00001440401,0.0007842571,0.001100207],"study_design_scores_gemma":[0.001832121,0.0002216087,0.9568222,0.00001525959,0.0001669889,0.000001467577,0.002355743,0.0006079965,0.03676003,0.0002553631,0.0007393936,0.0002218802],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991837,0.00653021,0.0006139358,0.0006084534,0.0000555039,0.0001743379,0.0001608121,0.000005745851,0.00001402222],"genre_scores_gemma":[0.9968584,0.00008923966,0.002055025,0.0004200106,0.00005868975,0.00006041575,0.0004001336,0.00001291829,0.00004516907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1961834,"threshold_uncertainty_score":0.478244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05154887072899671,"score_gpt":0.3251288993269068,"score_spread":0.2735800285979101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}