{"id":"W3138538328","doi":"10.1073/pnas.2015855118","title":"Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity","year":2021,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Division of Behavioral and Cognitive Sciences; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Compute Canada; Emory University; National Institutes of Health; National Science Foundation","keywords":"Biology; Immune system; Innate immune system; Primate; Stimulation; Pathogen; Genome; Immunology; Function (biology); Evolutionary biology; Gene; Genetics; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002365527,0.0002609586,0.000362185,0.0005485516,0.0004939109,0.0007642615,0.0001786503,0.0004242731,0.001306001],"category_scores_gemma":[0.0003827233,0.0002733321,0.0002575674,0.0003984776,0.0006385728,0.0003831265,0.0006128662,0.0006831846,0.0003267543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001614545,"about_ca_system_score_gemma":0.00013667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006358917,"about_ca_topic_score_gemma":0.001044629,"domain_scores_codex":[0.9997649,0.0000401077,0.000009619296,0.0001081857,0.00004264361,0.00003454182],"domain_scores_gemma":[0.9998168,0.00004698943,0.00004386518,0.00003272867,0.00002923384,0.00003041206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002433673,0.00002207722,0.01713772,0.0001620791,0.00006589658,0.0002130794,0.0007089464,0.0001781282,0.9683355,0.0003771194,0.0001129069,0.01244327],"study_design_scores_gemma":[0.00001472855,0.0006591909,0.9209094,0.00007866084,0.0001259108,0.002588218,0.00180048,0.001360109,0.05873464,0.002591843,0.01107974,0.00005698257],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939738,0.002086162,0.001515908,0.000145393,0.000008334408,0.000006458962,0.0003404304,0.00004221194,0.001881304],"genre_scores_gemma":[0.9945351,0.001283179,0.002068852,0.0001848441,0.00001850344,0.00003130804,0.0005900392,0.00002269004,0.001265514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306001,"threshold_uncertainty_score":0.00436902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03816799630882668,"score_gpt":0.3153023588447209,"score_spread":0.2771343625358942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}