{"id":"W3138553809","doi":"10.1101/2021.03.25.437029","title":"INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; Hospital for Sick Children; Princess Margaret Cancer Centre; University Health Network; Toronto Metropolitan University; University of Toronto; Ontario Institute for Cancer Research; Discovery Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Ontario; Leukemia and Lymphoma Society of Canada; University of Toronto; Temerty Faculty of Medicine, University of Toronto; Ontario Institute for Cancer Research; Canadian Institutes of Health Research; Leukemia and Lymphoma Society","keywords":"Biology; Cancer research; Stem cell; Lysosome; Biogenesis; Myeloid leukemia; Haematopoiesis; Hematopoietic stem cell; Leukemia; Mechanism (biology); Cell biology; Gene; Immunology; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001623421,0.000242779,0.000244636,0.0002316992,0.0002242844,0.0005173397,0.0001970657,0.0002907429,0.006187452],"category_scores_gemma":[0.0001169844,0.0001373966,0.0001844756,0.0001849954,0.0002180374,0.0001465738,0.0003984947,0.0006370808,0.002102623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000477321,"about_ca_system_score_gemma":0.0002744625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006631643,"about_ca_topic_score_gemma":0.0008701635,"domain_scores_codex":[0.9998902,0.00001598704,0.000007382178,0.00002069838,0.00004250246,0.00002315517],"domain_scores_gemma":[0.9999323,0.00001314568,0.00001286839,0.00001043227,0.000007895022,0.00002339171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001035623,0.00002674965,0.0002466542,0.00004881149,0.000006312024,0.0000825255,0.00001551273,0.0001977429,0.9962503,0.0007052802,0.0006376621,0.00167886],"study_design_scores_gemma":[0.0000297482,0.00003535321,0.002529234,0.00000943117,0.000006100997,0.0001987853,0.00003536762,0.003212585,0.9803412,0.0003793503,0.01321911,0.000003806469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491137,0.002577441,0.02173303,0.001687437,0.0003029711,0.00008316321,0.00342202,0.000960857,0.02011938],"genre_scores_gemma":[0.965461,0.001066861,0.006819794,0.0002314969,0.00003180247,0.00004349996,0.002384493,0.0003394645,0.02362153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006187452,"threshold_uncertainty_score":0.02069902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670804892437786,"score_gpt":0.2366304263686395,"score_spread":0.2199223774442617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}