{"id":"W3138612398","doi":"10.1016/j.arr.2021.101324","title":"Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases","year":2021,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Université de Tunis El Manar; Université Libanaise; Foundation for Science and Technology; Ministère de l'Europe et des Affaires Étrangères; European Cooperation in Science and Technology; Université Monastir; Agence Nationale de la Recherche; Université de Béjaïa; Providence Health Care","keywords":"Oxidative stress; Oxysterol; Autophagy; Peroxisome; Programmed cell death; Cholesterol; Phospholipidosis; Biology; Macular degeneration; Pharmacology; Oxidative phosphorylation; Mitochondrion; Biochemistry; Apoptosis; Medicine; Receptor; Phospholipid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002983171,0.000470036,0.002959746,0.0003604516,0.0001894891,0.00008981506,0.0002883506,0.0003286776,0.00001689581],"category_scores_gemma":[0.001824311,0.0003033003,0.0007557771,0.0006335189,0.0004379191,0.0001396683,0.0002756176,0.0007173985,0.000004005473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000530877,"about_ca_system_score_gemma":0.0001918415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000324839,"about_ca_topic_score_gemma":0.000003171344,"domain_scores_codex":[0.9945506,0.001729053,0.001687955,0.0007959363,0.0007659846,0.0004704794],"domain_scores_gemma":[0.9967341,0.0008321316,0.0008980702,0.0009347972,0.0003519235,0.0002489795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003944477,0.0002687636,0.000005261871,0.04187047,0.0002868275,0.00001893012,0.0001095585,1.752442e-7,0.002219481,0.0000497037,0.0004899696,0.9546414],"study_design_scores_gemma":[0.002095742,0.0005319011,0.0002844082,0.09173292,0.004950959,0.0001124065,0.00006139967,0.00005446102,0.0002774261,0.00009388776,0.8994806,0.0003238691],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01154502,0.9820945,0.0003152117,0.0001354869,0.0001674027,0.00561253,0.0000974298,0.00001469105,0.00001776972],"genre_scores_gemma":[0.002707522,0.9952854,0.0001809891,0.00003516941,0.0001766785,0.0008168131,0.0003345546,0.00008010989,0.0003827453],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9543176,"threshold_uncertainty_score":0.9999419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011405158605739,"score_gpt":0.4179315276351057,"score_spread":0.3167910117745317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}