{"id":"W3138612398","doi":"10.1016/j.arr.2021.101324","title":"Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases","year":2021,"lang":"en","type":"review","venue":"Ageing Research Reviews","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Université de Tunis El Manar; Université Libanaise; Foundation for Science and Technology; Ministère de l'Europe et des Affaires Étrangères; European Cooperation in Science and Technology; Université Monastir; Agence Nationale de la Recherche; Université de Béjaïa; Providence Health Care","keywords":"Oxidative stress; Oxysterol; Autophagy; Peroxisome; Programmed cell death; Cholesterol; Phospholipidosis; Biology; Macular degeneration; Pharmacology; Oxidative phosphorylation; Mitochondrion; Biochemistry; Apoptosis; Medicine; Receptor; Phospholipid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004350527,0.0009523278,0.001724267,0.001735867,0.0001818202,0.0008834957,0.0006680844,0.0009207355,0.004932782],"category_scores_gemma":[0.0004624724,0.0002196038,0.0005124083,0.001666466,0.0002908627,0.0007990158,0.0005465887,0.001341773,0.002338737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000370734,"about_ca_system_score_gemma":0.0006974147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097562,"about_ca_topic_score_gemma":0.001969637,"domain_scores_codex":[0.9998827,0.00001842987,0.00001652364,0.0000209284,0.00004488825,0.00001639272],"domain_scores_gemma":[0.9998217,0.00007189559,0.00003490983,0.000005260412,0.00004517383,0.00002100003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002768986,0.0001253829,0.0001365254,0.02273845,0.0002022247,0.0001742481,0.00003274306,0.0002372366,0.006840838,0.00197558,0.01635974,0.9509001],"study_design_scores_gemma":[0.0001173492,0.000316305,0.001849309,0.005401636,0.0005475465,0.000989222,0.00006337459,0.0001234452,0.002462918,0.001773775,0.9863197,0.0000354319],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001351669,0.9990749,0.00009239984,0.0001017846,0.0001013864,0.000003648129,0.00002323819,0.00000661787,0.0004607885],"genre_scores_gemma":[0.0005811094,0.9987187,0.0001357287,0.00008041407,0.00006253016,0.000004528707,0.00003356451,9.758958e-7,0.0003824268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004932782,"threshold_uncertainty_score":0.01650184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011405158605739,"score_gpt":0.4179315276351057,"score_spread":0.3167910117745317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}