{"id":"W3138633156","doi":"10.1002/gcc.22947","title":"Germline sequence analysis of <scp><i>RABL3</i></scp> in a large series of pancreatic ductal adenocarcinoma patients reveals no evidence of deleterious variants","year":2021,"lang":"en","type":"article","venue":"Genes Chromosomes and Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Ontario Institute for Cancer Research","funders":"Canadian Cancer Society Research Institute; National Cancer Institute; National Institutes of Health; Ontario Institute for Cancer Research; Rolfe Pancreatic Cancer Foundation; Gerald O. Mann Charitable Foundation; Government of Ontario; Lustgarten Foundation","keywords":"Pancreatic cancer; Germline; PALB2; Biology; Germline mutation; Cancer; Missense mutation; Allele; Adenocarcinoma; Gene; Oncology; Internal medicine; Cancer research; Genetics; Medicine; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003038742,0.0001619733,0.001283238,0.0002225779,0.00003268143,0.000005346941,0.0001055016,0.0001152555,0.0002682378],"category_scores_gemma":[0.0004833647,0.0001380018,0.0001377764,0.0009773977,0.0002289421,0.0001147257,0.0001146683,0.0001063599,0.000001215203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007098512,"about_ca_system_score_gemma":0.0005006763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006683823,"about_ca_topic_score_gemma":0.0003493776,"domain_scores_codex":[0.9981567,0.0001392912,0.0006649415,0.0003354874,0.0003786325,0.00032499],"domain_scores_gemma":[0.9983307,0.00029009,0.0002990566,0.0003557197,0.0006130486,0.0001113851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001450549,0.000218697,0.9025411,0.001286758,0.0009475207,0.00009326854,0.0008815155,0.000008164506,0.09310716,0.00002429026,0.00003819908,0.0007082701],"study_design_scores_gemma":[0.001378159,0.0007199385,0.985662,0.0009973275,0.001732667,0.00003062345,0.000352448,0.000515016,0.008466482,0.00002855632,0.00005550351,0.00006125466],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9602864,0.03893865,0.00001618513,0.00007143622,0.00005129956,0.0002591016,0.000248301,0.0000049176,0.0001236565],"genre_scores_gemma":[0.969864,0.02845611,0.0007047241,0.0000711996,0.00004075181,0.00005129302,0.000045676,0.00001263229,0.0007536029],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08464067,"threshold_uncertainty_score":0.562755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03558386382155976,"score_gpt":0.3307805124495549,"score_spread":0.2951966486279952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}