{"id":"W3138645123","doi":"10.1136/bmjopen-2020-043929","title":"Navigating choice in the face of uncertainty: using a theory informed qualitative approach to identifying potential patient barriers and enablers to participating in an early phase chimeric antigen receptor T (CAR-T) cell therapy trial","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; Institute for Clinical Evaluative Sciences; Genome British Columbia; University of Ottawa; Ottawa Hospital","funders":"National Cancer Institute","keywords":"Medicine; Chimeric antigen receptor; Qualitative research; Clinical trial; Knowledge translation; Family medicine; Cancer; Internal medicine; Immunotherapy; Knowledge management","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03825024,0.001129187,0.0009356978,0.002194096,0.01327975,0.006198292,0.003637703,0.003128753,0.003367302],"category_scores_gemma":[0.0512813,0.0009770938,0.0008630974,0.002027076,0.02086227,0.005657354,0.01010547,0.005710784,0.0003881492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01695556,"about_ca_system_score_gemma":0.02483974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05243865,"about_ca_topic_score_gemma":0.06731534,"domain_scores_codex":[0.9584596,0.03501615,0.0005830059,0.001265841,0.001472071,0.003203262],"domain_scores_gemma":[0.9174199,0.07045044,0.00313446,0.001511394,0.004005686,0.003478044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"qualitative","study_design_scores_codex":[0.00004764599,0.00003575694,0.001041044,0.0001450691,0.000004492251,0.0003299122,0.9929806,0.00007882271,0.0003289477,0.001533926,0.0004547069,0.003019119],"study_design_scores_gemma":[0.00001867598,0.0000408651,0.0003510479,0.0001607866,0.00000508401,0.00009951536,0.9926137,0.0002493263,0.0001927863,0.00136,0.004888877,0.00001930944],"study_design_candidate":"qualitative","study_design_consensus":"qualitative","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9493873,0.000948569,0.02282748,0.01191939,0.0001969768,0.003302581,0.0005221569,0.00006416074,0.01083147],"genre_scores_gemma":[0.9805156,0.0007918862,0.01078837,0.002451424,0.00002989183,0.002857232,0.0001312973,0.00003503813,0.002399248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05243865,"threshold_uncertainty_score":0.202289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2340563458959723,"score_gpt":0.5237100543812765,"score_spread":0.2896537084853041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}