{"id":"W3138658268","doi":"10.1186/s12967-021-03111-x","title":"Clinical outcomes and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacterial infections: a real-world multicenter study","year":2021,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Zhengzhou University; National Natural Science Foundation of China","keywords":"Medicine; Procalcitonin; Internal medicine; Polymyxin; Septic shock; Mortality rate; Polymyxin B; Mechanical ventilation; Gastroenterology; APACHE II; Univariate analysis; Carbapenem; Acinetobacter baumannii; Sepsis; Adverse effect; Antibiotics; Microbiology; Intensive care unit; Bacteria; Pseudomonas aeruginosa; Multivariate analysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003424069,0.0004818704,0.000686231,0.0005196317,0.000365564,0.0009963219,0.000432032,0.0006952235,0.0007357344],"category_scores_gemma":[0.005295817,0.0002599219,0.0007591499,0.0007918597,0.0005405178,0.0006928959,0.000588565,0.0005479995,0.0001387984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004490675,"about_ca_system_score_gemma":0.0004912642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000661629,"about_ca_topic_score_gemma":0.0005029325,"domain_scores_codex":[0.9973286,0.001564882,0.0002706148,0.0004296545,0.0002470262,0.000159192],"domain_scores_gemma":[0.9918919,0.00142479,0.004406146,0.0005235518,0.0006469115,0.001106719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006276873,0.001112238,0.9852019,0.0001191451,0.0006975292,0.0001787681,0.0001367533,0.0001714288,0.0008612916,0.00002309808,0.0002140682,0.005006871],"study_design_scores_gemma":[0.001049721,0.008354174,0.9873311,0.00003592255,0.0003837505,0.000645035,0.0003584591,0.0008595427,0.0003559729,0.00003627756,0.0005610397,0.00002882123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990528,0.0006162077,0.0000660775,0.00004004873,0.000005737008,0.00002116305,0.000119062,0.000001835337,0.0000770706],"genre_scores_gemma":[0.999427,0.000153206,0.00009310975,0.00004221117,0.00002611777,0.00002191972,0.0002171493,0.000001267747,0.00001807335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003424069,"threshold_uncertainty_score":0.01810837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02693551689330253,"score_gpt":0.3576118919933555,"score_spread":0.330676375100053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}