{"id":"W3138658268","doi":"10.1186/s12967-021-03111-x","title":"Clinical outcomes and safety of polymyxin B in the treatment of carbapenem-resistant Gram-negative bacterial infections: a real-world multicenter study","year":2021,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Zhengzhou University; National Natural Science Foundation of China","keywords":"Medicine; Procalcitonin; Internal medicine; Polymyxin; Septic shock; Mortality rate; Polymyxin B; Mechanical ventilation; Gastroenterology; APACHE II; Univariate analysis; Carbapenem; Acinetobacter baumannii; Sepsis; Adverse effect; Antibiotics; Microbiology; Intensive care unit; Bacteria; Pseudomonas aeruginosa; Multivariate analysis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005311812,0.0001037114,0.0004144872,0.00007177534,0.00002331408,0.000003910478,0.00007654428,0.00004990167,0.00003521557],"category_scores_gemma":[0.0002042411,0.00006058979,0.0001229977,0.0001135898,0.0001803214,0.00000651966,0.00000694423,0.00007207975,5.953471e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001404268,"about_ca_system_score_gemma":0.0001280091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001368576,"about_ca_topic_score_gemma":0.002161336,"domain_scores_codex":[0.9982826,0.0003202456,0.000963199,0.0001222428,0.0002344,0.00007733852],"domain_scores_gemma":[0.9988365,0.0003982412,0.000385962,0.0001403053,0.0002018767,0.00003715672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002099638,0.001412489,0.9616579,0.00001832778,0.0003619226,0.00002210474,0.001053515,0.00000927606,0.03219499,0.00006165767,0.0000175531,0.001090606],"study_design_scores_gemma":[0.006146057,0.002859958,0.9873021,0.00009302255,0.0001597276,0.000009263264,0.0009314222,0.000003996153,0.001821605,0.0000633552,0.0005619381,0.00004750856],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980227,0.0004441102,0.00007845165,0.0008325098,0.0002181705,0.0002142311,0.00002205179,5.381481e-7,0.0001672467],"genre_scores_gemma":[0.9978733,0.001249521,0.0005445691,0.00003515164,0.0002307828,0.000001580752,0.00001556173,0.000005895068,0.00004362779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03037339,"threshold_uncertainty_score":0.247078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02693551689330253,"score_gpt":0.3576118919933555,"score_spread":0.330676375100053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}