{"id":"W3138741565","doi":"10.1038/s41418-021-00766-3","title":"Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy","year":2021,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Genentech; Deutsche Forschungsgemeinschaft; Wellcome Trust; Ontario Genomics Institute; Indian Council of Agricultural Research; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Danish e-Infrastructure Cooperation; McGill University; Danmarks Grundforskningsfond; Bayer; Ministero della Salute; Pfizer","keywords":"Mitophagy; PINK1; Population; Mitochondrion; Biology; Genetics; Medicine; Autophagy; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838727,0.0003653975,0.0003347895,0.0001524979,0.0002433832,0.0003104355,0.0003231424,0.0005345474,0.002725592],"category_scores_gemma":[0.0004260011,0.000121218,0.0004249379,0.0001287778,0.0004100441,0.000194888,0.000220226,0.0005713696,0.0008112287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002416939,"about_ca_system_score_gemma":0.0001730775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006630237,"about_ca_topic_score_gemma":0.000638285,"domain_scores_codex":[0.9998516,0.00002614885,0.00002839057,0.0000435711,0.00002839899,0.00002188082],"domain_scores_gemma":[0.9997603,0.00007342959,0.00004778209,0.00004588048,0.00002228581,0.00005030083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001961982,0.00005311477,0.0005105787,0.00002728514,0.00002274471,0.0009537438,0.00001614005,0.0001431084,0.9965474,0.0002480021,0.0000799073,0.001201896],"study_design_scores_gemma":[0.0002012265,0.0009718518,0.01788452,0.00002501831,0.0001432391,0.01472049,0.0001125387,0.005320654,0.9528252,0.0003195943,0.007433241,0.0000423183],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993861,0.0006713364,0.003767959,0.0002013948,0.0001086762,0.0000329514,0.0006316709,0.00004073595,0.0006842956],"genre_scores_gemma":[0.9965231,0.0001734683,0.001472714,0.00009935546,0.00001735745,0.00002147676,0.0007904242,0.0000298909,0.0008722293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002725592,"threshold_uncertainty_score":0.009118021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768778270505402,"score_gpt":0.2455343682963564,"score_spread":0.2278465855913024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}