{"id":"W3138741565","doi":"10.1038/s41418-021-00766-3","title":"Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy","year":2021,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Genentech; Deutsche Forschungsgemeinschaft; Wellcome Trust; Ontario Genomics Institute; Indian Council of Agricultural Research; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Danish e-Infrastructure Cooperation; McGill University; Danmarks Grundforskningsfond; Bayer; Ministero della Salute; Pfizer","keywords":"Mitophagy; PINK1; Population; Mitochondrion; Biology; Genetics; Medicine; Autophagy; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000239864,0.00006304521,0.0001369133,0.00004620568,0.00003804805,0.000006528138,0.00001047359,0.00004116499,0.0001189549],"category_scores_gemma":[0.00001221905,0.00005235429,0.0000285084,0.00004436125,0.00002471492,0.00004252788,0.00000785682,0.00003992396,7.151914e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005654239,"about_ca_system_score_gemma":0.00003402753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002614297,"about_ca_topic_score_gemma":6.081829e-7,"domain_scores_codex":[0.9995568,0.00002500657,0.0001400441,0.000117079,0.0001068665,0.00005418117],"domain_scores_gemma":[0.9997001,0.00002053585,0.00008986549,0.00005821884,0.00008966814,0.0000416577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001157472,0.0001457558,0.007532619,0.0001463524,0.00003161653,0.000008113747,0.0001013819,1.556078e-7,0.9875396,0.00387853,0.000002985458,0.000497108],"study_design_scores_gemma":[0.000686083,0.00009365436,0.4797402,0.0000379419,0.00004214114,0.000006571687,0.00001332209,0.000182634,0.5188537,0.0003109869,0.000004616302,0.00002808893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998475,0.000883918,0.0001147609,0.00005032574,0.0001013754,0.00009162703,0.00001587399,0.000007039926,0.0002600639],"genre_scores_gemma":[0.9988512,0.0002483581,0.00001268364,0.00008552569,0.00004751428,0.000003596431,0.0003633201,0.000004129444,0.0003836594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4722076,"threshold_uncertainty_score":0.2134946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01768778270505402,"score_gpt":0.2455343682963564,"score_spread":0.2278465855913024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}