{"id":"W3138744410","doi":"10.3390/cancers13061331","title":"Early, On-Treatment Levels and Dynamic Changes of Genomic Instability in Circulating Tumor DNA Predict Response to Treatment and Outcome in Metastatic Breast Cancer Patients","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Fondation du cancer du sein du Québec","keywords":"Metastatic breast cancer; Medicine; Breast cancer; Genome instability; Internal medicine; Oncology; Cancer; Cell-free fetal DNA; Circulating tumor DNA; Gastroenterology; DNA; Biology; DNA damage; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002368601,0.0001642943,0.0001953542,0.0002695005,0.000120263,0.0002826944,0.0001157703,0.0002687374,0.001030703],"category_scores_gemma":[0.001091955,0.00007381625,0.00012352,0.0002202434,0.0001201855,0.0001417176,0.0001180732,0.000313002,0.0001652751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034997,"about_ca_system_score_gemma":0.0001163643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004252491,"about_ca_topic_score_gemma":0.0005696942,"domain_scores_codex":[0.9999043,0.00002231964,0.000007411925,0.00002151726,0.00002608789,0.00001833091],"domain_scores_gemma":[0.999441,0.0001703693,0.0002055795,0.00001977022,0.00005969596,0.0001036431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001891825,0.00009246441,0.9803835,0.0000218895,0.00003650723,0.0001351764,0.0000639768,0.000323266,0.007658931,0.00001796478,0.0001236704,0.009250914],"study_design_scores_gemma":[0.00001555301,0.0006480555,0.9962363,0.000005133319,0.00002970525,0.000487233,0.00004636535,0.0005796122,0.00163055,0.00004296374,0.0002750347,0.000003522793],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989955,0.0004297129,0.0001254951,0.00002538437,0.000003173938,0.00000543402,0.0001028637,0.000004141775,0.0003082132],"genre_scores_gemma":[0.9995731,0.00005497596,0.00009810286,0.00001075316,0.000006360592,0.000004447283,0.0001401364,0.000001112399,0.0001111766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001030703,"threshold_uncertainty_score":0.003448069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007954776087737,"score_gpt":0.2835646218827829,"score_spread":0.2634850741219055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}