{"id":"W3138750498","doi":"10.1016/j.stemcr.2021.03.001","title":"One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2","year":2021,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Neurogenesis and neuroplasticity mechanisms","field":"Neuroscience","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Seventh Framework Programme; Medical Research Council; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg; French Muscular Dystrophy Association; Agence Nationale de la Recherche; Horizon 2020; Novartis; National Multiple Sclerosis Society","keywords":"OLIG2; Biology; SOX10; Remyelination; Oligodendrocyte; Reprogramming; Cell biology; Myelin; DNA methylation; Cancer research; Neuroscience; Genetics; Gene expression; Cell; Gene; Central nervous system; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745726,0.0002919195,0.0002213552,0.0001275336,0.0001477732,0.0002746698,0.000191114,0.0001805671,0.001573897],"category_scores_gemma":[0.00008913778,0.0001002071,0.0002522909,0.0001062568,0.0001338446,0.0001098213,0.0002589066,0.0003377781,0.000535426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001191753,"about_ca_system_score_gemma":0.0002083117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006279522,"about_ca_topic_score_gemma":0.001756765,"domain_scores_codex":[0.9998652,0.00001435218,0.00001611103,0.00003789923,0.0000419776,0.0000245253],"domain_scores_gemma":[0.9999279,0.000013561,0.0000134318,0.00001790779,0.00001132843,0.00001590709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008778089,0.00005320962,0.0003598261,0.00003856019,0.000007348282,0.00009694087,0.00003628909,0.00005632139,0.9942678,0.000174732,0.00009993335,0.004721222],"study_design_scores_gemma":[0.0000123479,0.0001389826,0.001879489,0.000004573806,0.00001529291,0.0002365679,0.00002618157,0.000358577,0.9910171,0.00004154907,0.006264408,0.000004867403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9495668,0.001933492,0.03507572,0.0001243216,0.0002190734,0.000527652,0.002090133,0.0002944411,0.01016842],"genre_scores_gemma":[0.952083,0.001370572,0.01944675,0.0000990784,0.0000216857,0.0002991247,0.001950697,0.00005097085,0.02467808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001573897,"threshold_uncertainty_score":0.005265176,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02082520148064623,"score_gpt":0.2400126690573413,"score_spread":0.219187467576695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}