{"id":"W3138756438","doi":"10.1016/j.devcel.2021.03.010","title":"Balancing energy demand and production by mitochondrial trafficking of RHEB","year":2021,"lang":"en","type":"letter","venue":"Developmental Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; RHEB; Pyruvate dehydrogenase complex; mTORC1; Mitochondrion; Cell biology; Energy metabolism; Biochemistry; Enzyme; Signal transduction; PI3K/AKT/mTOR pathway; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001654294,0.000587811,0.0008301451,0.0003429402,0.001214928,0.002123222,0.0008036493,0.01372956,0.002931228],"category_scores_gemma":[0.007412673,0.0003546496,0.0005397085,0.0002325504,0.001844365,0.001490418,0.000743237,0.01541021,0.002533984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00246282,"about_ca_system_score_gemma":0.0008974479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007608138,"about_ca_topic_score_gemma":0.00136277,"domain_scores_codex":[0.9993431,0.0001657075,0.00007534952,0.00009061624,0.0002164755,0.0001088073],"domain_scores_gemma":[0.997867,0.001327191,0.000133669,0.0001224647,0.00025623,0.0002933573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001298393,0.0001072808,0.00150046,0.0001741381,0.00004509902,0.0103456,0.00015522,0.0003962241,0.008582377,0.01857644,0.9157763,0.04304251],"study_design_scores_gemma":[0.0007576271,0.0002488646,0.002398602,0.0001754984,0.00005628212,0.006738617,0.0003306305,0.002900013,0.009043515,0.04663523,0.9306261,0.00008904874],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003427332,0.004613578,0.0006290792,0.9488118,0.0383314,0.00001992021,0.0000631923,0.00006106913,0.00404258],"genre_scores_gemma":[0.07746588,0.008034883,0.001657419,0.7363756,0.1496774,0.0001513262,0.00008738856,0.00009186864,0.02645824],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01372956,"threshold_uncertainty_score":0.01786911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007007268137627963,"score_gpt":0.1909084660935909,"score_spread":0.1839011979559629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}