{"id":"W3138756438","doi":"10.1016/j.devcel.2021.03.010","title":"Balancing energy demand and production by mitochondrial trafficking of RHEB","year":2021,"lang":"en","type":"letter","venue":"Developmental Cell","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; RHEB; Pyruvate dehydrogenase complex; mTORC1; Mitochondrion; Cell biology; Energy metabolism; Biochemistry; Enzyme; Signal transduction; PI3K/AKT/mTOR pathway; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00006512824,0.0002570171,0.0002874125,0.00006093537,0.0000720633,0.0000204399,0.0001019111,0.0006845006,0.00008038744],"category_scores_gemma":[0.00003649652,0.0002711658,0.00007718199,0.00007180315,0.00007094676,0.000003315404,0.0001051636,0.0002759438,0.000003395136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001942015,"about_ca_system_score_gemma":0.0001498089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001663259,"about_ca_topic_score_gemma":0.0000218304,"domain_scores_codex":[0.9985549,0.0001104902,0.0003199956,0.0006159297,0.0001601253,0.0002385538],"domain_scores_gemma":[0.9995354,0.00001300688,0.0001698466,0.0001722819,0.00006585136,0.00004362558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002241675,0.00001473474,0.00007213889,0.00006365413,0.0000256563,0.0000143576,0.0000378567,0.000001184723,0.4850507,4.533724e-7,0.5142993,0.0003974873],"study_design_scores_gemma":[0.0002480194,0.00004558228,0.00000949525,0.00002348091,0.00001670543,0.00008838368,0.00003014752,0.000001007215,0.4402294,0.000002430528,0.5591201,0.0001852464],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.8131785,0.02785211,0.0151533,0.07800851,0.03728911,0.001998642,0.0006152599,0.0001692502,0.02573534],"genre_scores_gemma":[0.1069806,0.009929739,0.04496108,0.5191599,0.04011583,0.0003627799,0.05786969,0.0007147773,0.2199056],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7061979,"threshold_uncertainty_score":0.9999741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007007268137627963,"score_gpt":0.1909084660935909,"score_spread":0.1839011979559629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}