{"id":"W3138769060","doi":"10.1093/toxsci/kfab039","title":"High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization","year":2021,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada","keywords":"Spheroid; Potency; Hepatocyte; Primary (astronomy); Transcriptome; Throughput; Chemistry; In vitro; Computational biology; Pharmacology; Biology; Biochemistry; Computer science; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002604321,0.0003062259,0.0005907408,0.0005243002,0.0002831317,0.000416666,0.0001201538,0.0002837743,0.0006290058],"category_scores_gemma":[0.0002229829,0.0001366437,0.000466923,0.0008008013,0.0002061913,0.0001892056,0.0001965824,0.0004141929,0.0003522563],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002698952,"about_ca_system_score_gemma":0.0003380395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001145741,"about_ca_topic_score_gemma":0.002518827,"domain_scores_codex":[0.9997696,0.00002310004,0.00001570423,0.00007047095,0.00009192687,0.00002922646],"domain_scores_gemma":[0.9998453,0.00004371696,0.0000236916,0.00001294763,0.00006255551,0.00001176012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008915683,0.00001653464,0.00123297,0.00008489395,0.00001084552,0.00003733374,0.00003851626,0.0001819797,0.9966304,0.00002242997,0.00006973104,0.001585325],"study_design_scores_gemma":[0.00001655128,0.0008451563,0.08791389,0.00002824177,0.0001434063,0.0002917362,0.0004491822,0.004723613,0.9004129,0.0001684833,0.004975075,0.00003185778],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532318,0.003547479,0.01799201,0.0001769461,0.0001054662,0.0002275841,0.02250007,0.0001874181,0.002031276],"genre_scores_gemma":[0.9413359,0.004676752,0.02731986,0.0003605757,0.00007564753,0.0008907174,0.02048748,0.00008150785,0.004771647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001145741,"threshold_uncertainty_score":0.00227809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04499452656818119,"score_gpt":0.3081230472999751,"score_spread":0.2631285207317939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}