{"id":"W3138769060","doi":"10.1093/toxsci/kfab039","title":"High-Throughput Transcriptomic Analysis of Human Primary Hepatocyte Spheroids Exposed to Per- and Polyfluoroalkyl Substances as a Platform for Relative Potency Characterization","year":2021,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"Health Canada","keywords":"Spheroid; Potency; Hepatocyte; Primary (astronomy); Transcriptome; Throughput; Chemistry; In vitro; Computational biology; Pharmacology; Biology; Biochemistry; Computer science; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006598557,0.0002118752,0.0005132204,0.0001150186,0.0005530194,0.00009713204,0.0004419971,0.0001437689,0.00327498],"category_scores_gemma":[0.0000951313,0.0001612617,0.0001609422,0.001940211,0.0009595544,0.0006726317,0.0001545894,0.0001313229,0.0000248345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000181554,"about_ca_system_score_gemma":0.00006454526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002311169,"about_ca_topic_score_gemma":0.001377088,"domain_scores_codex":[0.997411,0.0001166473,0.0004409396,0.0007821891,0.0006947683,0.0005544764],"domain_scores_gemma":[0.9991608,0.0002111583,0.0001379646,0.0002050657,0.00003871522,0.0002462683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001020094,0.0001673425,0.03721246,0.00001146449,0.0000666305,0.000007073012,0.001294171,0.0001286994,0.9237449,0.00238348,0.0000340901,0.03484771],"study_design_scores_gemma":[0.0008019715,0.00236854,0.7748718,0.00002380941,0.0002159561,0.000006120029,0.0007318247,0.001173517,0.2124027,0.004096495,0.002775491,0.0005317628],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925134,0.001083,0.00174227,0.0006481041,0.00007275031,0.0004833843,0.00008920517,0.00003495445,0.003332909],"genre_scores_gemma":[0.9941903,0.0002950796,0.003948481,0.000512673,0.0000277176,0.00007971143,0.00006399371,0.000007294269,0.00087478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7376593,"threshold_uncertainty_score":0.9976361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04499452656818119,"score_gpt":0.3081230472999751,"score_spread":0.2631285207317939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}