{"id":"W3138818958","doi":"10.1182/blood.2020009081","title":"Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital; University Health Network","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Venetoclax; Cancer research; Medicine; Leukemia; Immunology; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003167936,0.0001311331,0.0002426856,0.0000639181,0.00008263245,0.00003149052,0.00006729738,0.0001021483,0.0008616227],"category_scores_gemma":[0.0003447917,0.0001290521,0.00007103768,0.0003963125,0.00006361955,0.00009346539,0.00004568335,0.0003162379,0.00005925618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001630443,"about_ca_system_score_gemma":0.0005651066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002184638,"about_ca_topic_score_gemma":0.00001697162,"domain_scores_codex":[0.9985774,0.0001629379,0.0001455654,0.0004011068,0.0003993208,0.0003137213],"domain_scores_gemma":[0.9991822,0.0001025053,0.00005770314,0.000380119,0.0001466882,0.0001307762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002181288,0.000518095,0.008052908,0.0001017949,0.00006539794,0.00007529918,0.0001021935,0.00000103771,0.9854441,4.035851e-7,0.0009066521,0.004514021],"study_design_scores_gemma":[0.001782599,0.0001214228,0.008762174,0.00006953166,0.00008024582,0.0001856664,0.00004671388,0.00004658515,0.9840407,0.000008316661,0.004737886,0.000118179],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939055,0.001515345,0.00001131657,0.0003066879,0.0001760173,0.0003275596,0.00001087771,0.00009451096,0.003652181],"genre_scores_gemma":[0.9923854,0.0005905797,0.000144007,0.00006533805,0.0004138796,0.00002543446,0.00008349768,0.0000331209,0.006258783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004395842,"threshold_uncertainty_score":0.9434164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551792651846018,"score_gpt":0.2820436404530037,"score_spread":0.2665257139345436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}