{"id":"W3138818958","doi":"10.1182/blood.2020009081","title":"Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital; University Health Network","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Venetoclax; Cancer research; Medicine; Leukemia; Immunology; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008836003,0.0002073686,0.0001635863,0.0002014312,0.00008478387,0.0001810378,0.0001182719,0.0001544438,0.001531634],"category_scores_gemma":[0.0001208971,0.00006157293,0.0001143739,0.000138931,0.0001235792,0.0001556041,0.000114224,0.0005178383,0.0001651076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001273312,"about_ca_system_score_gemma":0.0001214851,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003197524,"about_ca_topic_score_gemma":0.0006032562,"domain_scores_codex":[0.9999371,0.00001990189,0.000004689764,0.00001089003,0.00001213652,0.00001538559],"domain_scores_gemma":[0.9999448,0.00001796787,0.00001307461,0.000005961675,0.000004034418,0.0000141243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000749712,0.0001979629,0.0003940047,0.00007419116,0.000009086758,0.0000497501,0.00002263315,0.0001383704,0.9839932,0.00008922727,0.0001218508,0.01416001],"study_design_scores_gemma":[0.0002288744,0.007573323,0.01014539,0.0000110639,0.00005244524,0.000498508,0.00002129083,0.001097926,0.9750096,0.0000571705,0.005298093,0.000006359709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928227,0.003918592,0.000795089,0.00007439777,0.00003304358,0.0000349472,0.0001150762,0.00009961343,0.002106617],"genre_scores_gemma":[0.9969795,0.0011362,0.0008270125,0.00002421135,0.00002425503,0.0000142582,0.0001222578,0.000004024226,0.0008683659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531634,"threshold_uncertainty_score":0.005123794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551792651846018,"score_gpt":0.2820436404530037,"score_spread":0.2665257139345436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}