{"id":"W3138839669","doi":"10.1002/glia.23997","title":"Astrocyte‐mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome","year":2021,"lang":"en","type":"article","venue":"Glia","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Fondation Brain Canada; FRAXA Research Foundation","keywords":"Purinergic receptor; Astrocyte; Biology; Synaptogenesis; Fragile X syndrome; Cell biology; Purinergic signalling; FMR1; Neuroscience; P2Y receptor; Neuroinflammation; Knockout mouse; Receptor; Immunology; Extracellular; Central nervous system; Biochemistry; Adenosine receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004364352,0.0001135364,0.0001407628,0.00003809937,0.00001839449,0.000007534812,0.00009829312,0.00009621794,0.00005448898],"category_scores_gemma":[0.00002910343,0.0001257363,0.00005717195,0.0001241105,0.00002739095,0.000001822036,0.0001098545,0.00005989497,0.000006866905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007007676,"about_ca_system_score_gemma":0.00009123624,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009343323,"about_ca_topic_score_gemma":0.00001453277,"domain_scores_codex":[0.9991885,0.00002149002,0.0002175845,0.0002721539,0.0001062691,0.000193941],"domain_scores_gemma":[0.9996333,0.000004102533,0.00004936651,0.0002022184,0.00005870798,0.00005236544],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002195629,0.00007342473,0.0008608681,0.00001829897,0.00002084187,0.00001072543,0.00005450066,0.01045701,0.9881691,0.000004552218,0.0002434032,0.00006525993],"study_design_scores_gemma":[0.0005985745,0.00006415619,0.002683379,0.00001374694,0.000005189216,0.000005177886,0.00004230901,0.005277722,0.9908718,0.00005258905,0.0002431112,0.000142211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990633,0.0002987905,0.0001890022,0.00005284149,0.00005790222,0.00006375186,0.00006468517,0.000005985426,0.0002037297],"genre_scores_gemma":[0.9975021,0.0001230205,0.001091674,0.0001612952,0.000003471434,0.000008485733,0.0001822182,0.00001849521,0.0009092383],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005179293,"threshold_uncertainty_score":0.5127377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009269215837405307,"score_gpt":0.2077645530314519,"score_spread":0.1984953371940466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}