{"id":"W3138839669","doi":"10.1002/glia.23997","title":"Astrocyte‐mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome","year":2021,"lang":"en","type":"article","venue":"Glia","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research; Fondation Brain Canada; FRAXA Research Foundation","keywords":"Purinergic receptor; Astrocyte; Biology; Synaptogenesis; Fragile X syndrome; Cell biology; Purinergic signalling; FMR1; Neuroscience; P2Y receptor; Neuroinflammation; Knockout mouse; Receptor; Immunology; Extracellular; Central nervous system; Biochemistry; Adenosine receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002127544,0.0009262264,0.000437594,0.001188702,0.0003419981,0.0005121508,0.0003220872,0.0008873909,0.002537003],"category_scores_gemma":[0.0001374674,0.0004647792,0.0005217733,0.0003056842,0.0004706759,0.0003175551,0.0002973001,0.00112503,0.0006276572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004975423,"about_ca_system_score_gemma":0.0002268742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009947356,"about_ca_topic_score_gemma":0.001631551,"domain_scores_codex":[0.9996347,0.00003872082,0.00004871699,0.00009279469,0.0001122809,0.00007272919],"domain_scores_gemma":[0.9997029,0.00002313929,0.0001237125,0.00002306898,0.0000222262,0.0001049371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002581034,0.00007557567,0.0002704627,0.00004209747,0.00001144389,0.0004040173,0.00003634366,0.00007137777,0.998193,0.0001136635,0.00005752006,0.0004664865],"study_design_scores_gemma":[0.00008262454,0.001432149,0.01594173,0.00003603765,0.00009217372,0.001935106,0.0002108278,0.00201559,0.9758139,0.0001579496,0.002261065,0.00002092888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930196,0.0009591505,0.002863504,0.0002118544,0.00007711056,0.00008389531,0.001400403,0.0002313792,0.001153147],"genre_scores_gemma":[0.9886335,0.001066273,0.003138374,0.00009448595,0.00002144314,0.0002905896,0.0009305698,0.00006209466,0.005762721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002537003,"threshold_uncertainty_score":0.008487165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009269215837405307,"score_gpt":0.2077645530314519,"score_spread":0.1984953371940466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}