{"id":"W3138888243","doi":"10.1021/acs.est.0c05942","title":"Development of a Comprehensive Toxicity Pathway Model for 17α-Ethinylestradiol in Early Life Stage Fathead Minnows (<i>Pimephales promelas</i>)","year":2021,"lang":"en","type":"article","venue":"Environmental Science & Technology","topic":"Reproductive biology and impacts on aquatic species","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; McGill University; St. Francis Xavier University; Global Institute for Water Security; University of Saskatchewan","funders":"Environment and Climate Change Canada; University of Saskatchewan; Genome Canada; Government of Canada; McGill University","keywords":"Pimephales promelas; Vitellogenin; Minnow; Toxicity; Biology; Gonad; Toxicology; Environmental toxicology; Danio; Embryo; Andrology; Zoology; Physiology; Fish <Actinopterygii>; Internal medicine; Endocrinology; Cell biology; Genetics; Fishery; Zebrafish; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002944545,0.0006355873,0.0003995022,0.0003916675,0.0002534899,0.0004203532,0.0004395617,0.0004369339,0.001151517],"category_scores_gemma":[0.0001326515,0.0002604001,0.000745783,0.0001636334,0.0002474418,0.0004650271,0.0004778224,0.0006034672,0.0003337783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007071313,"about_ca_system_score_gemma":0.000854125,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003152837,"about_ca_topic_score_gemma":0.004278448,"domain_scores_codex":[0.9998723,0.0000107762,0.000008623222,0.00004797658,0.00004176993,0.00001864333],"domain_scores_gemma":[0.9999133,0.00000966164,0.00002886525,0.00001019099,0.00002061677,0.00001730382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001376641,0.00004227785,0.001851095,0.0001367455,0.00002376549,0.00008237486,0.00002472941,0.00326002,0.9909109,0.0004979774,0.0001390302,0.002893435],"study_design_scores_gemma":[0.0000724538,0.001824409,0.02475132,0.00005151417,0.0002366766,0.0003921571,0.0002091679,0.05152904,0.902523,0.001740716,0.01660622,0.00006325376],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8867834,0.00182711,0.09734404,0.0003591962,0.00009667486,0.0005664332,0.006653761,0.0008361635,0.005533079],"genre_scores_gemma":[0.9240913,0.003116948,0.05462722,0.0002734933,0.00001616778,0.0009193054,0.00695777,0.0001261514,0.009871568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003152837,"threshold_uncertainty_score":0.006268978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02353529815732718,"score_gpt":0.2569090104212147,"score_spread":0.2333737122638875,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}