{"id":"W3138913229","doi":"10.3389/fncir.2021.648624","title":"Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors","year":2021,"lang":"en","type":"review","venue":"Frontiers in Neural Circuits","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Neuroscience; Muscarinic acetylcholine receptor; Prefrontal cortex; Working memory; Neuromodulation; Psychology; Cholinergic; Muscarinic acetylcholine receptor M4; Stimulation; Cognition; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002909095,0.0004173943,0.00128083,0.0001969065,0.00004753733,0.00003304136,0.0002455234,0.0005264259,0.00001467466],"category_scores_gemma":[0.00006250474,0.0004393807,0.0004794327,0.000263559,0.00007423446,0.00001324359,0.0001565288,0.0004408458,2.964597e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001168517,"about_ca_system_score_gemma":0.000139396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002856234,"about_ca_topic_score_gemma":0.00001371365,"domain_scores_codex":[0.9975541,0.0003862325,0.0006288125,0.0008441517,0.000216192,0.0003705015],"domain_scores_gemma":[0.9990864,0.00002366251,0.0004147874,0.0003546528,0.000031575,0.00008893078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000009287934,0.0000717461,0.0004334183,0.001670385,0.0001139293,0.00001177768,0.00007375202,0.00004092144,0.01514267,0.000001276666,0.0001961066,0.9822347],"study_design_scores_gemma":[0.01261153,0.004371078,0.00885113,0.06786371,0.005048388,0.001031336,0.003321597,0.009395532,0.03970315,0.0001427167,0.8334609,0.01419889],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09506776,0.902641,0.0001661076,0.000002881442,0.001392237,0.0005712538,0.0000274684,0.000007818302,0.0001234583],"genre_scores_gemma":[0.1977877,0.8015005,0.00006638683,0.00001332126,0.0000906554,0.00004522376,0.0003288485,0.00006298204,0.0001043994],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9680358,"threshold_uncertainty_score":0.9998058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557436438933029,"score_gpt":0.2691246321365066,"score_spread":0.2435502677471763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}