{"id":"W3138913229","doi":"10.3389/fncir.2021.648624","title":"Neuromodulation of Persistent Activity and Working Memory Circuitry in Primate Prefrontal Cortex by Muscarinic Receptors","year":2021,"lang":"en","type":"review","venue":"Frontiers in Neural Circuits","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Canada First Research Excellence Fund","keywords":"Neuroscience; Muscarinic acetylcholine receptor; Prefrontal cortex; Working memory; Neuromodulation; Psychology; Cholinergic; Muscarinic acetylcholine receptor M4; Stimulation; Cognition; Receptor; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002581228,0.0005985783,0.0006594964,0.001323971,0.0001441666,0.0005081962,0.0006038826,0.0007034416,0.00147354],"category_scores_gemma":[0.0002751608,0.0001789411,0.0002861755,0.0009600304,0.0002920924,0.0007681652,0.0003838212,0.000976937,0.001147845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004878088,"about_ca_system_score_gemma":0.0006139334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000767609,"about_ca_topic_score_gemma":0.001513584,"domain_scores_codex":[0.9999453,0.000008198559,0.000008997171,0.00001108907,0.00001967346,0.00000679387],"domain_scores_gemma":[0.9999201,0.00002929401,0.00001566235,0.000002683757,0.00002276204,0.000009541043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009904209,0.00005041449,0.0001680746,0.01630581,0.00007837534,0.0002710749,0.00006231994,0.0004284214,0.01018198,0.004173034,0.01767917,0.9505023],"study_design_scores_gemma":[0.0000282452,0.0001662355,0.002179311,0.00306385,0.0001307543,0.002290666,0.00005466945,0.0001859415,0.002946372,0.00323706,0.9856893,0.00002767339],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000282456,0.9979876,0.0001759604,0.0001813679,0.0001152606,0.000004783423,0.00002311872,0.000009852572,0.001219609],"genre_scores_gemma":[0.001091417,0.9978333,0.0002080387,0.000158793,0.00009176177,0.00000676415,0.00003563351,0.000001255912,0.0005729885],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00147354,"threshold_uncertainty_score":0.004929483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02557436438933029,"score_gpt":0.2691246321365066,"score_spread":0.2435502677471763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}