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Chan School of Public Health; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; World Health Organization; Wageningen University and Research; Cancer Research UK; Génome Québec; Swedish Cancer Foundation; McGill University; Breast Cancer Research Foundation; Petrus och Augusta Hedlunds Stiftelse; Johns Hopkins University; Centre International de Recherche sur le Cancer; Pelotonia; Brigham and Women's Hospital; Canadian Cancer Society Research Institute; Pancreatic Cancer UK; Ovarian Cancer Research Fund; U.S. Department of Health and Human Services; National Cancer Research Institute; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Cancer Research Institute","keywords":"Mendelian randomization; Medicine; Internal medicine; Colorectal cancer; Genome-wide association study; Oncology; Single-nucleotide polymorphism; Blood pressure; Odds ratio; Prostate cancer; Cancer; Genotype; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001089915,0.0002741756,0.0003075633,0.0005478118,0.0001817334,0.0005106827,0.0004071724,0.0002569898,0.001357469],"category_scores_gemma":[0.003573518,0.00009579919,0.0004205013,0.001011097,0.000435516,0.0001394611,0.0003885568,0.0003164535,0.00008313257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003167931,"about_ca_system_score_gemma":0.000305574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002551393,"about_ca_topic_score_gemma":0.001727974,"domain_scores_codex":[0.9982247,0.0007459872,0.0001246753,0.000548153,0.0002802649,0.00007620631],"domain_scores_gemma":[0.9966602,0.0008692522,0.001639975,0.000475455,0.0002054114,0.0001497406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001655825,0.00008147527,0.9580472,0.0001835909,0.001554583,0.0003435868,0.0001086298,0.002015349,0.01945477,0.001180274,0.0002522173,0.0151226],"study_design_scores_gemma":[0.00005377032,0.0002759424,0.9908561,0.00002523871,0.0005736132,0.0006014176,0.00004456607,0.001651836,0.004065888,0.0007130081,0.001122196,0.00001656471],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991197,0.001661961,0.004082255,0.0001312292,0.00001963207,0.00002522597,0.001584925,0.0000495652,0.001248202],"genre_scores_gemma":[0.9980156,0.0001573465,0.001284985,0.00003238494,0.00001235149,0.00001652463,0.0003098776,0.000005698716,0.0001651341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002551393,"threshold_uncertainty_score":0.005764067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206232702160898,"score_gpt":0.2689231033483833,"score_spread":0.2468607763267743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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