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Chan School of Public Health; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; World Health Organization; Wageningen University and Research; Cancer Research UK; Génome Québec; Swedish Cancer Foundation; McGill University; Breast Cancer Research Foundation; Petrus och Augusta Hedlunds Stiftelse; Johns Hopkins University; Centre International de Recherche sur le Cancer; Pelotonia; Brigham and Women's Hospital; Canadian Cancer Society Research Institute; Pancreatic Cancer UK; Ovarian Cancer Research Fund; U.S. Department of Health and Human Services; National Cancer Research Institute; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Cancer Research Institute","keywords":"Mendelian randomization; Medicine; Internal medicine; Colorectal cancer; Genome-wide association study; Oncology; Single-nucleotide polymorphism; Blood pressure; Odds ratio; Prostate cancer; Cancer; Genotype; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472707,0.0001962739,0.0008115307,0.0001298383,0.00003307517,0.000007569309,0.00005002039,0.0002045445,0.0000612864],"category_scores_gemma":[0.0001255062,0.0001593729,0.0001540885,0.0001075911,0.0002091111,0.0000191427,0.0001537598,0.0003614131,0.000001085627],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000424707,"about_ca_system_score_gemma":0.0002539471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005079987,"about_ca_topic_score_gemma":0.0001020371,"domain_scores_codex":[0.9985502,0.0001397887,0.0004590964,0.0003345209,0.0003764639,0.0001399161],"domain_scores_gemma":[0.9985145,0.00008663133,0.000322593,0.0003857281,0.0005780874,0.000112426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005747993,0.0003433524,0.327944,0.001287974,0.001082084,0.0001784442,0.001809919,0.0002322812,0.6305338,0.0001614956,0.0001660276,0.03568578],"study_design_scores_gemma":[0.001164369,0.0001344083,0.8384253,0.000807806,0.0008481806,0.00003891685,0.0002844188,0.00517128,0.1522302,0.0004047028,0.0003078397,0.0001825548],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985661,0.01273839,0.0001119494,0.000633891,0.0001433298,0.0004017815,0.00002753295,0.00001785812,0.0002642342],"genre_scores_gemma":[0.9894361,0.009260247,0.0008435225,0.0002260154,0.00005389648,0.000009540098,0.00008589047,0.00002655256,0.00005827188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5104812,"threshold_uncertainty_score":0.649904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02206232702160898,"score_gpt":0.2689231033483833,"score_spread":0.2468607763267743,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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