{"id":"W3139003502","doi":"10.15252/embr.202051280","title":"Toll-like receptor 4 is activated by platinum and contributes to cisplatin-induced ototoxicity","year":2021,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Women and Children's Health Research Institute; Canada Research Chairs; Government of Canada; Canadian Institutes of Health Research; Kids With Cancer Society; Alberta Cancer Foundation; International Society for Advancement of Cytometry","keywords":"Ototoxicity; Cisplatin; TLR4; Toll-like receptor; In vivo; Cancer research; Lipopolysaccharide; Pharmacology; Chemistry; Receptor; Immunology; Medicine; Biology; Innate immune system; Internal medicine; Biochemistry; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003405985,0.0004894751,0.0005158377,0.0005522902,0.0002840894,0.0006381004,0.0003186432,0.000596739,0.002621581],"category_scores_gemma":[0.0005511311,0.0002844726,0.0007445315,0.0001977073,0.0004005532,0.000415897,0.0008373141,0.0007940442,0.0005126768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004548788,"about_ca_system_score_gemma":0.0004052211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003058139,"about_ca_topic_score_gemma":0.0004016299,"domain_scores_codex":[0.9995189,0.0001129471,0.00005888871,0.0000507756,0.0001395628,0.0001190025],"domain_scores_gemma":[0.999666,0.00003073978,0.0001642283,0.0000355969,0.00004423304,0.00005922519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002614163,0.0002127132,0.009147356,0.0003325675,0.0001132841,0.002186501,0.00007497956,0.0004227218,0.9741426,0.0004548072,0.0006143912,0.009683807],"study_design_scores_gemma":[0.0003265412,0.002799153,0.2061423,0.0001346711,0.0005872205,0.009398911,0.0008798838,0.006451506,0.7574964,0.002044801,0.01367334,0.00006527187],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987358,0.006162694,0.002926562,0.0007878282,0.0001790015,0.00008416887,0.0002216447,0.00009607154,0.002184122],"genre_scores_gemma":[0.9965391,0.00145417,0.0004309482,0.0001045542,0.00003989664,0.00002918082,0.000121435,0.000008089154,0.001272586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002621581,"threshold_uncertainty_score":0.008770108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00845607913448342,"score_gpt":0.2352110568129046,"score_spread":0.2267549776784211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}