{"id":"W3139028616","doi":"10.1002/jbmr.4288","title":"Insertion Mutation in Tnfrsf11a Causes a Paget's Disease–Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice","year":2020,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Bone health and treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Medical Research Council; European Commission; Medical Research Council Canada; Wellcome Trust","keywords":"Osteopetrosis; RANKL; Osteoclast; Osteolysis; Bone resorption; Biology; Mutation; Cancer research; Osteoblast; Bone disease; Macrophage colony-stimulating factor; Endocrinology; Internal medicine; RANK Ligand; Bone marrow; Immunology; Medicine; Activator (genetics); Genetics; Osteoporosis; Receptor; In vitro; Gene; Macrophage","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003412762,0.001364519,0.0004822481,0.001392324,0.0003589299,0.0004189205,0.0005074643,0.001288846,0.00328239],"category_scores_gemma":[0.0002183262,0.0006199627,0.0007714814,0.0004298552,0.0005462202,0.0002006664,0.0004101353,0.0008960014,0.001348694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003526193,"about_ca_system_score_gemma":0.0002398103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000713762,"about_ca_topic_score_gemma":0.001151398,"domain_scores_codex":[0.9994066,0.000084044,0.0001101578,0.0001438883,0.0001520926,0.0001032025],"domain_scores_gemma":[0.9994202,0.00006785987,0.0002696163,0.00004386576,0.00002745201,0.00017115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002071266,0.0001442495,0.0006169854,0.00005120514,0.00003169859,0.001390443,0.00002704228,0.00009918682,0.9959404,0.0002531098,0.0001431362,0.001095354],"study_design_scores_gemma":[0.0009687408,0.00219395,0.04355782,0.0001397755,0.000299119,0.03001213,0.0002253276,0.004401978,0.9051926,0.0005445214,0.0123836,0.00008033951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876979,0.000950906,0.006117748,0.0002073216,0.00009076478,0.0001514484,0.002318816,0.0005498664,0.001915204],"genre_scores_gemma":[0.9850802,0.0009490997,0.005272774,0.0001649441,0.00004820155,0.0001687559,0.002417865,0.0001503971,0.005747713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00328239,"threshold_uncertainty_score":0.01098073,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06782963483770038,"score_gpt":0.3660182139497484,"score_spread":0.298188579112048,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}