{"id":"W3139030169","doi":"10.3390/ijms22062957","title":"Implication of EZH2 in the Pro-Proliferative and Apoptosis-Resistant Phenotype of Pulmonary Artery Smooth Muscle Cells in PAH: A Transcriptomic and Proteomic Approach","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"EZH2; Cancer research; Cell cycle; Apoptosis; Transcriptome; Biology; Gene knockdown; Cell growth; Cell biology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001233762,0.0002669147,0.0002320373,0.0003291891,0.0001627327,0.0002319397,0.0001179214,0.0002641724,0.0005937653],"category_scores_gemma":[0.0001018637,0.00008788885,0.0002175525,0.0001913647,0.000188411,0.0002457811,0.0001716547,0.0003839067,0.0001846629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001443364,"about_ca_system_score_gemma":0.0001183581,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002407523,"about_ca_topic_score_gemma":0.0004148898,"domain_scores_codex":[0.9999285,0.000007791567,0.000005894091,0.0000207548,0.00002346023,0.00001370187],"domain_scores_gemma":[0.9999398,0.00001154126,0.00001722461,0.000005552383,0.00001104038,0.00001486269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001110031,0.000009806082,0.00076864,0.0000581416,0.000009670021,0.00009305215,0.00001092872,0.00003071184,0.9976674,0.0000337704,0.0000209035,0.001186013],"study_design_scores_gemma":[0.00002107471,0.0002786908,0.1010285,0.00001413522,0.000109929,0.001557432,0.0001236182,0.001874446,0.8906942,0.0002132841,0.004071699,0.00001302279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841966,0.005464005,0.007875527,0.000247143,0.00004462752,0.00003349403,0.001231766,0.00007369744,0.0008332618],"genre_scores_gemma":[0.9862142,0.003447286,0.006400057,0.0001804116,0.00004608203,0.00004767982,0.001748038,0.00001604616,0.001900095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005937653,"threshold_uncertainty_score":0.001986325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01483446525301752,"score_gpt":0.2625956675943355,"score_spread":0.247761202341318,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}