{"id":"W3139054633","doi":"10.1007/978-1-0716-0947-7_12","title":"First-Order Correction of Statistical Significance for Screening Two-Way Epistatic Interactions","year":2021,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Epistasis; Computer science; Order (exchange); Computational biology; Genetics; Econometrics; Biology; Statistics; Mathematics; Gene; Economics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1333337,0.005394168,0.01343257,0.009973857,0.008576492,0.00597725,0.0126971,0.009564399,0.02776157],"category_scores_gemma":[0.323158,0.003208026,0.0142923,0.01120632,0.007971194,0.007526307,0.005318844,0.02009651,0.004110601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003842619,"about_ca_system_score_gemma":0.01015036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009020628,"about_ca_topic_score_gemma":0.009011311,"domain_scores_codex":[0.705671,0.1912548,0.01996883,0.05003276,0.02439487,0.008677699],"domain_scores_gemma":[0.5099447,0.4051504,0.006997851,0.0648249,0.009786355,0.003295765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.01752788,0.005486251,0.1626544,0.01002943,0.06508453,0.02185542,0.009715755,0.03028152,0.05026311,0.1081786,0.04716589,0.4717572],"study_design_scores_gemma":[0.00344275,0.01302777,0.2185826,0.002192914,0.01662842,0.01477559,0.003966142,0.4094296,0.05782791,0.194472,0.06379911,0.001855273],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04816108,0.001276343,0.936496,0.0005935571,0.002207789,0.001449867,0.002202022,0.00532003,0.002293374],"genre_scores_gemma":[0.3579257,0.0003158028,0.6217496,0.001135396,0.000379839,0.00570863,0.001725521,0.003486618,0.007572839],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1333337,"threshold_uncertainty_score":0.7051443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03066727607894697,"score_gpt":0.4185840405888,"score_spread":0.387916764509853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}