{"id":"W3139057214","doi":"10.1038/s41388-021-01692-x","title":"CRISPR/Cas9 library screening uncovered methylated PKP2 as a critical driver of lung cancer radioresistance by stabilizing β-catenin","year":2021,"lang":"en","type":"article","venue":"Oncogene","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Radioresistance; Biology; Cancer research; DNA repair; Lung cancer; Cancer; Carcinogenesis; Wnt signaling pathway; Cell biology; Genetics; Oncology; Signal transduction; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199195,0.0002180165,0.0002919123,0.0000466711,0.00009390779,0.00003384002,0.0001675873,0.0002782554,0.0004548325],"category_scores_gemma":[0.0001636947,0.0002440658,0.0001605112,0.0003493602,0.0001225842,0.00002299452,0.0001629091,0.0001348015,0.000003087533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005911882,"about_ca_system_score_gemma":0.0004512874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009911684,"about_ca_topic_score_gemma":0.00005510481,"domain_scores_codex":[0.9982909,0.0001520285,0.0003736765,0.0005620293,0.0002578115,0.0003635323],"domain_scores_gemma":[0.9990777,0.00004947736,0.0001319785,0.0003945142,0.000206883,0.0001393819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000235718,0.00005885023,0.002290254,0.00006845392,0.00020044,0.00001559337,0.0000525367,0.0006862581,0.9836606,0.00006822784,0.009375123,0.003287915],"study_design_scores_gemma":[0.0007988321,0.00008237647,0.0006000351,0.0001039242,0.000116817,0.00001773968,0.00005616707,0.0006710905,0.9762937,0.00007645271,0.02090208,0.0002807913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9377556,0.05284459,0.006666229,0.0008781241,0.0002966261,0.0001930586,0.0002667236,0.00003600665,0.001063008],"genre_scores_gemma":[0.9894966,0.001733619,0.00559072,0.0002228954,0.0002453186,0.00003189243,0.0005521522,0.00007050126,0.002056339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05174093,"threshold_uncertainty_score":0.9952716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007325634074607817,"score_gpt":0.2902555966083687,"score_spread":0.2829299625337609,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}