{"id":"W3139061917","doi":"10.1007/s12250-021-00363-1","title":"The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA Pol II from Binding to HIV-1 LTR","year":2021,"lang":"en","type":"article","venue":"Virologica Sinica","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"CREB; Transcription (linguistics); Response element; Biology; Coactivator; Transcription factor; Gene expression; Cell biology; Molecular biology; Virology; Gene; Promoter; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003010471,0.0002833308,0.0003734898,0.00006546531,0.001270651,0.00008720559,0.0003680578,0.0003738079,0.002108458],"category_scores_gemma":[0.0002631321,0.0001977777,0.0002156185,0.0002696768,0.0002239775,0.0001516226,0.0001067076,0.0004642467,0.00137968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008125551,"about_ca_system_score_gemma":0.00008532812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008442551,"about_ca_topic_score_gemma":0.00004611914,"domain_scores_codex":[0.9972063,0.0008051306,0.0004707012,0.0006615611,0.0001135865,0.0007426754],"domain_scores_gemma":[0.9986839,0.0005041517,0.0001187476,0.0005101934,0.00008362427,0.0000993603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006304671,0.0004495962,0.0003195612,0.00000536469,0.0003934174,0.00002178508,0.0004593783,0.000003911417,0.9568374,0.00006166776,0.03496831,0.005849203],"study_design_scores_gemma":[0.001765921,0.0005009375,0.004560553,0.00003742874,0.00009982482,0.00001762449,0.0004055726,0.000004367966,0.6204838,0.0001199707,0.3717936,0.0002104862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982128,0.005002221,0.0002665299,0.009069901,0.0003993706,0.0005217341,0.001513979,0.0001643665,0.0009339114],"genre_scores_gemma":[0.986055,0.000599605,0.0001691891,0.0002673889,0.00005187314,0.0001153919,0.00277582,0.00002517814,0.00994061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3368253,"threshold_uncertainty_score":0.9993979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01875151524871035,"score_gpt":0.2554963851962753,"score_spread":0.2367448699475649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}