{"id":"W3139107210","doi":"10.3389/fcvm.2021.647405","title":"Stepwise Reversion of Multiply Mutated Recombinant Antitrypsin Reveals a Selective Inhibitor of Coagulation Factor XIa as Active as the M358R Variant","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cardiovascular Medicine","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; McMaster University","funders":"Health Canada; Canadian Blood Services; Australian Government; Government of Canada; Heart and Stroke Foundation of Canada","keywords":"Serpin; Chemistry; Proteases; Factor IX; Elastase; Molecular biology; Thrombin; Antithrombotic; Mutagenesis; Biology; Biochemistry; Mutation; Enzyme; Immunology; Gene; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335841,0.0003342369,0.000196059,0.0001204124,0.00007989746,0.0002513447,0.0002999119,0.0002769613,0.0008757084],"category_scores_gemma":[0.0001608258,0.0001051733,0.0002573401,0.0001542757,0.0001505729,0.00008823903,0.0001441874,0.0004703964,0.0003084771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002429091,"about_ca_system_score_gemma":0.0001329197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001058909,"about_ca_topic_score_gemma":0.0009054651,"domain_scores_codex":[0.9998424,0.00002422343,0.0000168585,0.0000327623,0.00004165586,0.0000421233],"domain_scores_gemma":[0.9999326,0.00001551501,0.00002065868,0.000007258173,0.000007985012,0.00001592796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001673318,0.00005060873,0.0001192885,0.00001369994,0.0000115138,0.0001262224,0.00001713106,0.0001532953,0.9980562,0.0001591566,0.00006176349,0.001063816],"study_design_scores_gemma":[0.0000328151,0.0005515491,0.001508115,0.000004162179,0.0000238614,0.0004150388,0.00001721398,0.002701232,0.9923706,0.00003553626,0.00233058,0.000009370558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966853,0.0003873789,0.001327004,0.00007234357,0.00002542557,0.00001808382,0.0001928871,0.00006481695,0.00122681],"genre_scores_gemma":[0.9965623,0.0001861976,0.001310277,0.00004147235,0.000005297087,0.000009070785,0.0003079127,0.00002717241,0.001550191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058909,"threshold_uncertainty_score":0.002929568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01255974312505598,"score_gpt":0.2530258256692358,"score_spread":0.2404660825441798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}