{"id":"W3139137833","doi":"10.21203/rs.3.rs-69968/v1","title":"Plasma Levels of Phosphorylated Tau 181 Are Associated With Cerebral Metabolic Dysfunction in Cognitively Impaired Individuals","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"National Institute on Aging; Fonds de Recherche du Québec - Santé; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; UK Dementia Research Institute; IXICO; H. Lundbeck A/S; Servier; Vetenskapsrådet; Eisai; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; EU Joint Programme – Neurodegenerative Disease Research; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; Weston Brain Institute; Northern California Institute for Research and Education; Demensförbundet; Novartis Pharmaceuticals Corporation; Biogen; BioClinica; Gun och Bertil Stohnes Stiftelse; Consortium canadien en neurodégénérescence associée au vieillissement; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; University of Southern California; F. Hoffmann-La Roche; Hjärnfonden; European Commission; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Phosphorylation; Neuroscience; Psychology; Internal medicine; Medicine; Endocrinology; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002122101,0.0003817509,0.0003283081,0.0007646916,0.0003507583,0.0004798737,0.0002422931,0.0005008152,0.001761051],"category_scores_gemma":[0.000892795,0.0002809155,0.0002897526,0.0006359358,0.0001956111,0.0002111448,0.0002525147,0.0004481968,0.0002992075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001316309,"about_ca_system_score_gemma":0.0001068178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00224467,"about_ca_topic_score_gemma":0.001647927,"domain_scores_codex":[0.9999061,0.00001523243,0.00001132043,0.00003535829,0.00001604369,0.00001588518],"domain_scores_gemma":[0.9994028,0.00009286752,0.0003103376,0.00004609269,0.00006255408,0.00008536384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007104005,0.00006686776,0.9933838,0.00001689466,0.0001568074,0.0002727428,0.0001108455,0.00009691964,0.00316953,0.0000176744,0.0001072767,0.001890247],"study_design_scores_gemma":[0.00000495164,0.00006918333,0.9991822,0.000001700742,0.00002651475,0.0003293986,0.00003264718,0.0001154846,0.0001719612,0.00002452548,0.00003980639,0.000001721829],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995406,0.0001152845,0.00004225658,0.00001361028,0.000002423583,0.000001594418,0.0001373211,0.00000329862,0.000143676],"genre_scores_gemma":[0.9995524,0.00005208288,0.00006372322,0.00001080017,0.000006922214,0.000002806387,0.0001738878,0.000001755582,0.0001355432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00224467,"threshold_uncertainty_score":0.005891323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08398305306431304,"score_gpt":0.3688574889406256,"score_spread":0.2848744358763126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}