{"id":"W3139271143","doi":"10.1161/atvbaha.121.315931","title":"VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"","keywords":"Thrombomodulin; Angiogenesis; Podosome; Sprouting angiogenesis; Sprouting; ROCK2; VEGF receptors; Cell biology; Cancer research; Chemistry; Biology; Thrombin; Neovascularization; Immunology; Kinase; Rho-associated protein kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003002844,0.0004288797,0.000562047,0.00007161131,0.0003538171,0.00007849529,0.0002486283,0.0004419309,0.0001577592],"category_scores_gemma":[0.00004984522,0.000392054,0.0004444237,0.0001525828,0.0001329204,0.00001842359,0.0004596145,0.0001144705,0.00002757883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002679905,"about_ca_system_score_gemma":0.00009360194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001094489,"about_ca_topic_score_gemma":0.0001069046,"domain_scores_codex":[0.9973497,0.0003190915,0.0004766347,0.001068644,0.0001797098,0.0006062083],"domain_scores_gemma":[0.9987466,0.00002944647,0.0001794867,0.0006930676,0.0001648154,0.000186574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007208898,0.0001306701,0.04576175,0.00002507555,0.0003089914,4.24505e-7,0.0001085018,0.000004199719,0.951758,0.00005383282,0.00009743102,0.001743864],"study_design_scores_gemma":[0.001216601,0.0003674768,0.3196172,0.00007591788,0.0001389925,0.000006270816,0.0001963763,0.00003735553,0.6735303,0.0000971819,0.004119996,0.0005963107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935569,0.001323605,0.003948265,0.0001993514,0.0004713573,0.0002136281,0.00008234128,0.00004231626,0.0001622589],"genre_scores_gemma":[0.9902565,0.006821085,0.001042436,0.0008772361,0.0005920645,0.00008072118,0.000238552,0.00007152902,0.00001989301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2782278,"threshold_uncertainty_score":0.9998531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421833613452133,"score_gpt":0.283919570179158,"score_spread":0.2497012340446367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}