{"id":"W3139271143","doi":"10.1161/atvbaha.121.315931","title":"VEGF-Induced Endothelial Podosomes via ROCK2-Dependent Thrombomodulin Expression Initiate Sprouting Angiogenesis","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services; University of British Columbia","funders":"","keywords":"Thrombomodulin; Angiogenesis; Podosome; Sprouting angiogenesis; Sprouting; ROCK2; VEGF receptors; Cell biology; Cancer research; Chemistry; Biology; Thrombin; Neovascularization; Immunology; Kinase; Rho-associated protein kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008977637,0.0001940066,0.0001490561,0.0001286831,0.0001058396,0.0001636487,0.0001015321,0.0001901466,0.00139981],"category_scores_gemma":[0.0000913235,0.00007895811,0.0002876217,0.00006730743,0.0001240401,0.0001826405,0.0001643167,0.0004546287,0.0002982646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002088929,"about_ca_system_score_gemma":0.00013915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002530719,"about_ca_topic_score_gemma":0.0003568538,"domain_scores_codex":[0.9999083,0.00001504162,0.000007664496,0.00001796466,0.00002176287,0.00002921185],"domain_scores_gemma":[0.9999117,0.000008471126,0.00003084087,0.00000787376,0.00001214104,0.00002900184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000101982,0.0000188693,0.0001753052,0.00003979202,0.000003083885,0.0000845773,0.00001121167,0.00002348293,0.9987698,0.0001548424,0.0000508207,0.0005661533],"study_design_scores_gemma":[0.00003508435,0.000198612,0.006734975,0.000007939548,0.00001235596,0.0003474237,0.00002589246,0.001211038,0.9886806,0.0000742296,0.002669153,0.00000272061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924194,0.0009350033,0.004268171,0.0001038361,0.00003477857,0.00004591471,0.0002258713,0.0001278889,0.001839117],"genre_scores_gemma":[0.9940744,0.0003612847,0.002210862,0.00003373495,0.00001171138,0.0000474001,0.0002965839,0.00001525663,0.002948872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00139981,"threshold_uncertainty_score":0.004682839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03421833613452133,"score_gpt":0.283919570179158,"score_spread":0.2497012340446367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}